Tumor Suppressor Genes Flashcards Preview

Step 1 > Tumor Suppressor Genes > Flashcards

Flashcards in Tumor Suppressor Genes Deck (12):
1

Rb

Associated Tumor: Retinoblastoma,osteosarcoma
Gene product: Inhibits E2F; blocks G1 -> S phase

2

p53

Associated Tumor: Most human cancers; Li-Fraumeni syndrome
Gene product: Transcription factor for p21, blocks G1 -> S phase

3

BRCA1

Associated Tumor: Breast and ovarian cancer
Gene product: DNA repair protein

4

BRCA2

Associated Tumor: Breast and ovarian cancer
Gene product: DNA repair protein

5

p16

Associated Tumor: Melanoma
Gene product:

6

BRAF

Associated Tumor: Melanoma
Gene product: B-raf

7

APC

Associated Tumor: Colorectal cancer (associated with FAP)
Gene product:

8

WT1

Associated Tumor: Wilms' Tumor (nephroblastoma)
Gene product:

9

NF1

Associated Tumor: NeuroFibromatosis type 1
Gene product: RAS GTPase activating protein (RAS-GAP)

10

NF2

Associated Tumor: NeuroFibromatosis type 2
Gene product: Merlin (schwannomin) protein

11

DPC4

Associated Tumor: Pancreatic cancer
Gene product: DPC - Deleted in Pancreatic Cancer

12

DCC

Associated Tumor: Colon cancer
Gene product: DCC - Deleted in Colon Cancer

Decks in Step 1 Class (119):