Important Cytokines Flashcards Preview

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Flashcards in Important Cytokines Deck (12):
1

IL-1

An endogenous pyrogen. Causes fever, acute inflammation. Activates endothelium to express adhesion molecules; induces chemokine secretion to recruit leukocytes.

2

IL-6

An endogenous pyrogen. Also secreted by Th2 cells. Causes fever and stimulates production of acute-phase proteins.

3

IL-8

Major chemotactic factor for neutrophils.
"Clean up on aisle 8". Neutrophils are recruited by IL-8 to clear infections.

4

IL-12

Induces differentiation of T cells into Th1 cells. Activates NK cells. Also secreted by B cells.

5

TNF-alpha

Mediates septic shock. Activates endothelium. Causes leukocyte recruitment, vascular leak.

6

"Hot T-Bone stEAk"

IL-1: fever (hot)
IL-2: stimulates T cells.
IL-3: stimulates Bone marrow.
IL-4: stimulates IgE production.
IL-5: stimulates IgA production.

7

IL-2

Stimulates growth of helper, cytotoxic and regulatory T cells.

8

IL-3

Supports the growth and differentiation of bone marrow stem cells. Functions like GM-CSF.

9

Interferon-Gama

Activates macrophages and Th1 cells. Suppresses Th2 cells. Has antiviral and antitumor properties.

10

IL-4

Induces differentiation into Th2 cells. Promotes growth of B cells. Enhances class switching to IgE and IgG.

11

IL-5

Promotes differentiation of B cells. Enhances class switching to IgA. Stimulates the growth and differentiation of eosinophils.

12

IL-10

Modulates inflammatory response. Inhibits actions of activated T cells and Th1. Also secreted by regulatory T cells.

TGF-Beta has similar actions to IL-10, because it is involved in inhibiting inflammation.

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