Clarithromycin Flashcards
1
Q
drug classification
A
macrolide antibiotic
2
Q
used to treat
A
bacterial infections:
acute otitis, pharyngitis, tonsillitis, respiratory tract infections
3
Q
brand names
A
biaxin
omeclamox
4
Q
mechanism of action
A
metabolised to 14-OH clarithromycin
active
works synergistically with parent compound
penetrates bacterial cell wall
reversibly binds to domain V of 23S ribosomal RNA of 50S subunit of bacterial ribosome
blocks translocation of aminoacyl transfer-RNA and polypeptide synthesis
inhibits hepatic microsomal CYP3A4 isoenzyme and P-glycoprotein an energy-dependent drug efflux pump
5
Q
side effects
A
nausea
vomiting
diarrhoea
bloating and indigestion
headaches
insomnia
6
Q
methods of administration
A
orally
in tablet form which is extended-release
liquid suspension
