Pethidine/ Meperidine Flashcards
1
Q
classification
A
opioid agonist with analgesic and sedative properties
2
Q
treatment
A
severe pain
3
Q
mechanism of action
A
kappa-opiate receptor agonist
local anaesthetic effects
exchanges GTP for GDP on G protein complex
inhibit adenylate cyclase
decrease intracellular cAMP
nociceptive neurotransmitters release is inhibited
inhibit release of ADH, somatostatin, insulin and glucagon
OP3 and OP1 receptor agonist resulting in hyperpolarisation and reduced neuronal excitability
