Prednisolone

Question 1

drug classification

Answer 1

glucocorticoid
small molecule

Question 2

what is the drug target

Answer 2

glucocorticoid receptors

Question 3

mechanism of action

Answer 3

lipophilic so defuses into the cells
binds to glucocorticoid receptors
homodimerizes
translocates into the nucleus
binds to specific promoters
initiates expression of certain genes
decreases transcription of IL-2

Question 4

physiology

Answer 4

decreased transcription of IL-2 reduces proliferation of T helper cells
inhibits neutrophil apoptosis
decrease vasodilation and permeability of capillaries
decrease leukocyte migration

Question 5

used to treat

Answer 5

adrenocortical insufficiency
inflammatory conditions

Question 6

lower doses VS higher doses

Answer 6

lower have anti-inflammatory effect
higher have immunosuppressive effect

Question 7

brand name

Answer 7

Millipred

Question 8

side effects

Answer 8

anxiety
cognitive impairment
electrolyte imbalance
fatigue
gastrointestinal discomfort