Vincristine Flashcards
1
Q
drug characteristics
A
vinka alkaloid
complex natural
anti-mitotic agent
half life 85 hours
2
Q
used to treat
A
acute leukaemia
malignant lymphoma
Hoskins disease
acute erythraemia
acute pnamyelosis
3
Q
brand names
A
marquibo
vincasar
4
Q
methods of administration
A
only intravenously
5
Q
mechanism of action
A
affects all proliferating cells
binds to free alpha and beta monomers
disrupts mictrotubule cytoskeleton
so chromatids can’t pull apart
6
Q
side effects
A
peripheral neuropathy
7
Q
how does peripheral neuropathy occur
A
microtubules are abundant in neurones as they make up axon skeleton and dendrites
change the neutron shape and stability and its ability to transmit a nerve impulse
8
Q
link to the PBL case
A
used in induction treatment in ALL
taken once weekly for 5 weeks
