Paracetamol

Question 1

chemistry

Answer 1

analgesic drug
antipyretic agent

Question 2

analgesic

Answer 2

pain management

Question 3

antipyretic agent

Answer 3

reduces fever

Question 4

mechanism of action

Answer 4

categorised along NSAIDs
weakly inhibits COX pathways
increases pain threshold as it inhibits COX1 and 2 involved in prostaglandin synthesis, responsible for causing pain
reduces prostaglandin E2 concentrations in thermoregulatory region of hypothalamus, controls fever

Question 5

specificity for

Answer 5

COX2

Question 6

COX

Answer 6

cyclooxygenase

Question 7

COX1

Answer 7

isoform involved in protecting gastric mucosa, regulating blood flow and clotting

Question 8

COX2

Answer 8

isoform induced in inflammation

Question 9

doesn’t inhibit COX where

Answer 9

peripheral tissues
so no peripheral anti-inflammatory effect

Question 10

antipyretic agents, how?

Answer 10

due to drugs direct action on heat-regulating centres in the brain
results in peripheral vasodilation
sweating
loss of body heat

Question 11

another name for paracetamol

Answer 11

acetaminophen

Question 12

side effects

Answer 12

very few
allergic reaction
low BP

Question 13

overdose

Answer 13

live failure
due to NAPQI (toxic metabolite) accumulation causes hepatocellular necrosis

Question 14

physiology

Answer 14

decrease in prostaglandin synthesis and sensation of pain