Trimethoprim Flashcards
1
Q
drug classification
A
antifolate antibiotic
2
Q
chemistry
A
combined with sulfamethoxazole
3
Q
used to treat
A
infections of the urinary tract, respiratory tract and gastrointestinal tract
4
Q
brand name
A
bactrim
polytrim
primsol
5
Q
mechanism of action
A
reversbile inhibitor of dihydrofolate reductase
reduces the synthesis of tetrahydrofolic acid
results in bactericidal activity
6
Q
trimethoprim given in combination with sulfamethoxazole
A
given together inhibit 2 consecutive steps in biosynthesis of bacterial nucleic acids and proteins
7
Q
side effects
A
headaches
itching or mild rash
nausea or vomiting
