CNS depressants and sedatives Flashcards Preview

Year 2 Pharmacology > CNS depressants and sedatives > Flashcards

Flashcards in CNS depressants and sedatives Deck (25):
1

what are the benzodiazepine sedative-hypnotic drugs?

1. flurazepam
2. temazepam
3. triazolam
4. midazolam

2

what are the benzodiazepine anxiolytic drugs?

1. alprazolam
2. clorazepate
3. diazepam
4. lorazepam
5. oxazepam

3

what are the benzodiazepine-like (Z) drugs?

1. zolpidem
2. eszopiclone

4

what is the serotonin agonist anxiolytic drug?

buspirone

5

what are the therapeutic uses for sedative-hypnotic drugs?

relief of anxiety and insomnia

6

which chemical moiety is responsible for the sedative-hypnotic effects of benzodiazepines?

electronegative substituent in the 7 position

7

where are benzodiazepines metabolized?

liver

8

what are the three metabolites of benzodiazepine metabolism? what are their half lives?

1. inactive soluble glucuronides (3-hydroxy benzos) - short half life
2. weakly active (triazolo benzos) - short half life
3. long lived active (2-keto benzos) - long half life

9

which benzodiazepine metabolites are not influenced by age? which ARE influenced by age?

1. not influenced by age - 3-hydroxy
2. influenced by age - 2-keto

10

what is the mechanism of action for benzodiazepines?

1. potentiate effects of GABA at GABAa receptors
2. increase frequency of opening and conductance

11

what are the major adverse effects of benzodiazepines?

1. respiratory depression
2. tolerance
3. anterograde amnesia
4. dependence
5. withdrawal

12

what is the function of flumazenil?

benzodiazepine antagonist

13

what is the mechanism of action of benzodiazepine antagonists?

compeititive inhibitor that binds to the BZ receptor - reverses effects of benzodiazepine

14

what is the clinical use for the benzodiazepine-like (Z) drugs?

insomnia

15

what are the barbiturate drugs?

1. pentobarbital
2. phenobarbital
3. thiopental

16

what are the clinical uses for the barbiturates?

1. anesthesia
2. sedative hypnotic
3. anticonvulsant
4. medically induced coma

17

what is the mechanism of action for barbiturates?

increase duration of GABA-gated chloride channel opening

18

what type of drug is ramelteon? what is the clinical use?

1. sedative
2. insomnia

19

what is the MOA of ramelteon?

melatonin receptor agonist

20

what type of drug is buspirone? what is the MOA?

1. NON-sedating anxiolytic
2. partial agonist at 5HT1a (auto)receptors

21

what is the beta blocker sedative hypnotic?

propanolol

22

what are the antihistamine sedative hypnotics?

1. hydroxyzine
2. diphenhydramine

23

flurazepam, temazepam, triazolam, midazolam are what type of drug? what is the MOA?

1. benzodiazepine sedative-hypnotic drugs
2. potentiate effects of GABA at GABAa receptors and increase frequency of opening and conductance

24

alprazolam, clorazepate, diazepam, lorazepam, and oxazepam are what type of drug? what is the MOA?

1. benzodiazepine anxiolytic drugs
2. potentiate effects of GABA at GABAa receptors and increase frequency of opening and conductance

25

zolpidem and eszopiclone are what type of drug? what is the MOA?

1. benzodiazepine-like (Z) drugs
2. potentiate effects of GABA at GABAa receptors and increase frequency of opening and conductance

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