Flashcards in Rheumatoid arthritis and migraine Deck (28):
what are the stages of RA?
chronic inflammation with tissue injury
what characterizes the amplification stage of RA?
T cell activation
what are the first line drugs for RA?
what are the other drug types for RA?
disease-modifying anti-rheumatic drugs (DMARDS)
do NSAIDs alter the progression of RA?
do DMARDs alter the progression of RA?
yes - slow progression
what are the two types of DMARDs?
what are the synthetic DMARDs?
antimetabolite / antifolate
cytostatic / cytotoxic
what is the first line DMARD agent for RA? which class is it in?
what class of drug is leflunomide? what is the MOA?
inhibits ribonucleotide synthesis cell cycle arrest
chloroquine and hydroxychloroquine are what type of drug?
what are the general MOAs of the biologic DMARDs?
cytokine receptor interactions
cell signaling proteins, inhibitors, ligands
what are the anti-TNF biologic DMARDs?
what is the IL-1 inhibitor DMARD?
what is the MOA of anakinra?
IL-1 receptor inhibitor
what is the MOA of etanercept and infliximab?
what is the treatment of choice for PREVENTION of migraines?
what are the prevention agents for migraines?
propanalol (b1 and b2)
which migraine drug class has adverse effects that include drowsiness, tremor, hair loss, blood and liver abnormalities, and teratogenicity?
which migraine drug class has adverse effects that include postaural symptoms and is contraindicated in patients with asthma?
when are NSAIDs used in migraines?
non specific pain therapy in acute migraine attacks
which drugs carry a risk of transforming migraines into a more severe, chronic form?
what are the antiemetic drugs used for acute migraine attacks?
what are the ergot derivative agents? what is the MOA?
vasoconstriction via alpha receptors and 5-HT receptors
what is the triptan drug? what is the MOA?
selective 5-HT1d and 5-HT1b receptor agonists
what are the contraindications of the triptan drugs?
restricted for presence of CV disease
what is the best treatment for migraines?