Rheumatoid arthritis and migraine Flashcards Preview

Year 2 Pharmacology > Rheumatoid arthritis and migraine > Flashcards

Flashcards in Rheumatoid arthritis and migraine Deck (28):
1

what are the stages of RA?

initiation
amplification
chronic inflammation with tissue injury

2

what characterizes the amplification stage of RA?

T cell activation

3

what are the first line drugs for RA?

NSAIDs

4

what are the other drug types for RA?

glucocorticoids
disease-modifying anti-rheumatic drugs (DMARDS)

5

do NSAIDs alter the progression of RA?

no

6

do DMARDs alter the progression of RA?

yes - slow progression

7

what are the two types of DMARDs?

synthetic
biologic

8

what are the synthetic DMARDs?

antimetabolite / antifolate
polypeptide abx
cytostatic / cytotoxic
antimalarial
gold compounds

9

what is the first line DMARD agent for RA? which class is it in?

methotrexate

antimetabolite

10

what class of drug is leflunomide? what is the MOA?

synthetic DMARD

inhibits ribonucleotide synthesis cell cycle arrest

11

chloroquine and hydroxychloroquine are what type of drug?

synthetic DMARDs

12

what are the general MOAs of the biologic DMARDs?

ab-ag interactions
cytokine receptor interactions
cell signaling proteins, inhibitors, ligands

13

what are the anti-TNF biologic DMARDs?

etanercept
infliximab

14

what is the IL-1 inhibitor DMARD?

anakinra

15

what is the MOA of anakinra?

IL-1 receptor inhibitor

16

what is the MOA of etanercept and infliximab?

anti-TNF

17

what is the treatment of choice for PREVENTION of migraines?

metoprolol (b1)

18

what are the prevention agents for migraines?

propanalol (b1 and b2)
metoprolol (b1)
amitryptyline
divalproex (valproate)
topiramate

19

which migraine drug class has adverse effects that include drowsiness, tremor, hair loss, blood and liver abnormalities, and teratogenicity?

anticonvulsants

20

which migraine drug class has adverse effects that include postaural symptoms and is contraindicated in patients with asthma?

beta blockers

21

when are NSAIDs used in migraines?

non specific pain therapy in acute migraine attacks

22

which drugs carry a risk of transforming migraines into a more severe, chronic form?

NSAIDs
opiates

23

what are the antiemetic drugs used for acute migraine attacks?

metoclopramide
chlorpromazine
prochlorperazine

24

what are the ergot derivative agents? what is the MOA?

ergotamine
dihydroergotamine

vasoconstriction via alpha receptors and 5-HT receptors

25

what is the triptan drug? what is the MOA?

sumatriptan

selective 5-HT1d and 5-HT1b receptor agonists

26

what are the contraindications of the triptan drugs?

restricted for presence of CV disease

27

what is the best treatment for migraines?

sleep

28

the triptan drugs relieve what migraine symptoms?

pain
nausea
photophobia

Decks in Year 2 Pharmacology Class (70):