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Year 2 Pharmacology > Toxicology II > Flashcards

Flashcards in Toxicology II Deck (17):
1

what is the antidote for warfarin poisoning?

vitamin K

2

what is the antidote for acute opioid poisoning?

naloxone

3

what is the long term therapy for opioid toxicity?

naltrexone

4

what is methemoglobinemia? what is the result?

state in which heme iron is in Fe3 state (ferric) and not Fe2 (ferrous) of normal Hb

unable to transport oxygen

5

what is the antidote for methemoglobinemia?

methylene blue

6

methylene blue is the antidote for what condition?

methemoglobinemia

7

definition: toxidrome

common, well characterized clinical syndromes that provide a symptomatic fingerprint of patterns of poisoning associated with specific intoxicants

8

which drugs can produce a sympathomimetic toxidrome? what are the pupillary, cardiac, and neuro symptoms?

cocaine, amphetamines, PCP

pupils - large
cardiac - HTN
neuro - tremor, hyperthermia

9

which drugs can produce a sedative / hypnotic toxidrome? what are the CNS, respiratory, pupillary, and cardiac symptoms?

alcohol, barbiturates, benzodiazepines

CNA - coma
respiration - decreased
pupils - miosis or mydriasis
cardiac - hypotension

10

which drugs can produce a opioid / opiate toxidrome? what are the CNS, respiratory, and pupillary symptoms?

opiates, morphine, codeine, propoxyphene, oxycodone, hydrocodone

CNS - coma
respiratory - depression
pupils - pinpoint

11

which drugs can produce an anticholinergic toxidrome? what are the CNS, pupillary, and 'other' symptoms?

anticholinergics, antidepressants

CNS - agitation
pupils - mydriasis
other - fever, dry skin, flushing, urinary retention

12

which drugs can produce a cholinergic toxidrome? what are the symptoms?

organophosphates, nicotine

pupils - ppp
other - fasciculations, incontinence, salivation, wheezing, lacrimation, bradycardia

13

which drugs can produce a tricyclic toxidrome? what are the CNS, pupillary, and cardiac symptoms?

TCAs

CNS - coma, agitation
pupils - mydriasis
cardiac - dysrhythmias, hypotension (alpha blockade)

14

which drugs can produce a salicylate toxidrome? what are the respiratory and 'other' symptoms?

aspirin

respiration - increase or normal
other - diaphoresis, tinnitus, agitation, alkalosis (early), acidosis (late), hyperpyrexia

15

what is the treatment for benzo toxicity?

flumazenil

16

what is a treatment for cocaine toxicity?

lidocaine

17

what is the treatment for acetaminophen toxicity?

n-acetylcysteine

Decks in Year 2 Pharmacology Class (70):