Flashcards in Complex Lipid Metabolism Deck (26):
3 carbon-acyl groups with 3 fatty acid groups (one per a carbon)
2 FA groups, 3 carbons, 1 phosphate group with a polar head group
What is unique about cardiolipin?
Has 2 phosphate groups with 4 FA groups (total, 2 per a P)
Synthesized in peroxisomes. Have alkenyl alcohol attached via ether linkage
Sphingosine + acyl-CoA+PC
Singaling molecule. Only the anime plus a saturated FA
shingosine, FA in amide linkage, 1 or more carb derived structures
2 sources of glycerol-3-phosphate
Liver (glycerol) and adipose tissue (dihydroxyacetone phosphate)
Where is glycerol kinase primarily expressed?
Liver and intestine
TAGS from liver fate
packaged/secreted as VLDL
TAGS from adipose fate
stored in lipid droplets of adipocytes
TAGs from intestine fate
Packaged as chylomircons for circulation
What tissue does not synthesize phsopholipids?
From what are all glycerophospholipids derived from?
What type of synthesis is DAG used for?
PC and PE
How is phosphatidic acid activate for cardiolipin and PI synthesis?
Addition of CTP (into CDP-DAG)
2 palmitic acids. Is an important component of lung surfactant
Components of PAF
1 alkyl ether, 1 acetylglyercol, 1phosphocholine
ceramide + 1 carb
Ceramide + 2 or more carbs
Globoside+ 1 or more sialic acids (aka NANAs)
Sphingolipidose. Deficient in beta-hexosaminidase. Gm2 accumulation. SS: blindness, seizures, cherry-red macula
Most common sphinolipidose. deficient in glucocerebrosidase. Glucocerebroside accumulation. Hepatosplenomegaly, long bone osteoporosis, severe neurological signs.
Sphingolipidose. Deficient in alpha-galactosidase A. Accumulation of trihexosylceramide. SS: angiokeratoma, renal damage, x-linked**
Sphingolipidose. Deficient in galactosylceramidase. Accumulation of galactosylceramide and galactosylsphingosine. SS: infantile onset, peripheral neuropathy, loss of myelin