Complex Lipid Metabolism Flashcards Preview

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Flashcards in Complex Lipid Metabolism Deck (26):
1

Triacylglycerol

3 carbon-acyl groups with 3 fatty acid groups (one per a carbon)

2

Phospholipids

2 FA groups, 3 carbons, 1 phosphate group with a polar head group

3

What is unique about cardiolipin?

Has 2 phosphate groups with 4 FA groups (total, 2 per a P)

4

Plasmalogens

Synthesized in peroxisomes. Have alkenyl alcohol attached via ether linkage

5

Sphingomyelin

Sphingosine + acyl-CoA+PC

6

Sphingosine

Singaling molecule. Only the anime plus a saturated FA

7

Glycoshingolipid composition

shingosine, FA in amide linkage, 1 or more carb derived structures

8

2 sources of glycerol-3-phosphate

Liver (glycerol) and adipose tissue (dihydroxyacetone phosphate)

9

Where is glycerol kinase primarily expressed?

Liver and intestine

10

TAGS from liver fate

packaged/secreted as VLDL

11

TAGS from adipose fate

stored in lipid droplets of adipocytes

12

TAGs from intestine fate

Packaged as chylomircons for circulation

13

What tissue does not synthesize phsopholipids?

RBCs

14

From what are all glycerophospholipids derived from?

phosphatidic acid

15

What type of synthesis is DAG used for?

PC and PE

16

How is phosphatidic acid activate for cardiolipin and PI synthesis?

Addition of CTP (into CDP-DAG)

17

Dipalmitoylphophatidylcholine

2 palmitic acids. Is an important component of lung surfactant

18

Components of PAF

1 alkyl ether, 1 acetylglyercol, 1phosphocholine

19

Cerebroside components

ceramide + 1 carb

20

Globoside

Ceramide + 2 or more carbs

21

Ganglioside

Globoside+ 1 or more sialic acids (aka NANAs)

22

Tay-Sachs

Sphingolipidose. Deficient in beta-hexosaminidase. Gm2 accumulation. SS: blindness, seizures, cherry-red macula

23

Gaucher

Most common sphinolipidose. deficient in glucocerebrosidase. Glucocerebroside accumulation. Hepatosplenomegaly, long bone osteoporosis, severe neurological signs.

24

Fabry

Sphingolipidose. Deficient in alpha-galactosidase A. Accumulation of trihexosylceramide. SS: angiokeratoma, renal damage, x-linked**

25

Krabbe

Sphingolipidose. Deficient in galactosylceramidase. Accumulation of galactosylceramide and galactosylsphingosine. SS: infantile onset, peripheral neuropathy, loss of myelin

26

Niemann-Pick

Sphingolipidose. Deficient in sphingomyelinase. Accumulation of sphingomyelin. SS: neuropathic/non-neuropathic forms, heptaoslpenomegaly, foamy cells in bone marrow