What regulates glucose entering the cell?
First step in glycolysis
Glucose to glucose-6-Pi (irreversable)
Where is hexokinase found?
All tissue types
Where is glucokinase found?
Liver and pancreatic beta cells
What is inhibited by G-6-P?
What is the function of glucokinase?
to remove glucose from the blood
What is the committed step of glycolysis?
F-6-P to F-1,6-BP. Uses one ATP. Is irreversible. Phosophofructokinase 1 (PFK1)
What inhibits enolase?
Fluoride, used to clinically determine BS
Pyruvate converted to acetyl-CoA
What is the third irreversable reaction of glycolysis?
PEP to pyruvate (pyruvate kinase). ATP formed
Lactate dehydrogenase forms Lactate
What is the primary purpose of anaerobic glycolysis?
Regeneration of NAD+
Why must NAD+ be regenerated for glycolysis?
NADH cannot cross the mitochondrial membrane
ATP production in glycolysis?
net gain of 2 ATP per a glucose molecule
What activates PFK-1?