Glycolysis Flashcards Preview

Biochem > Glycolysis > Flashcards

Flashcards in Glycolysis Deck (21):
1

What regulates glucose entering the cell?

Insulin

2

First step in glycolysis

Glucose to glucose-6-Pi (irreversable)

3

Where is hexokinase found?

All tissue types

4

Where is glucokinase found?

Liver and pancreatic beta cells

5

What is inhibited by G-6-P?

Hexokinase

6

What is the function of glucokinase?

to remove glucose from the blood

7

What is the committed step of glycolysis?

F-6-P to F-1,6-BP. Uses one ATP. Is irreversible. Phosophofructokinase 1 (PFK1)

8

What inhibits enolase?

Fluoride, used to clinically determine BS

9

Aerobic glycolysis

Pyruvate converted to acetyl-CoA

10

What is the third irreversable reaction of glycolysis?

PEP to pyruvate (pyruvate kinase). ATP formed

11

Anaerobic glycolysis

Lactate dehydrogenase forms Lactate

12

What is the primary purpose of anaerobic glycolysis?

Regeneration of NAD+

13

Why must NAD+ be regenerated for glycolysis?

NADH cannot cross the mitochondrial membrane

14

ATP production in glycolysis?

net gain of 2 ATP per a glucose molecule

15

What activates PFK-1?

F-2,6-BP, AMP

16

What inhibits PFK-1?

Citrates, ATP

17

What activates Pyruvate kinase?

F-2,6-BP, AMP

18

What inhibits pyruvate kinase?

Acetyl-CoA, ATP

19

What is 2-3BPG's affect on erythrocytes?

Decreased affinity for O2, so O2 is released

20

What type of carb metabloism is not affected by insulin?

Fructose metabolism

21

Glactosemia

lack of G-1-P uridyltransferase