Flashcards in Glycolysis Deck (21):
1
What regulates glucose entering the cell?
Insulin
2
First step in glycolysis
Glucose to glucose-6-Pi (irreversable)
3
Where is hexokinase found?
All tissue types
4
Where is glucokinase found?
Liver and pancreatic beta cells
5
What is inhibited by G-6-P?
Hexokinase
6
What is the function of glucokinase?
to remove glucose from the blood
7
What is the committed step of glycolysis?
F-6-P to F-1,6-BP. Uses one ATP. Is irreversible. Phosophofructokinase 1 (PFK1)
8
What inhibits enolase?
Fluoride, used to clinically determine BS
9
Aerobic glycolysis
Pyruvate converted to acetyl-CoA
10
What is the third irreversable reaction of glycolysis?
PEP to pyruvate (pyruvate kinase). ATP formed
11
Anaerobic glycolysis
Lactate dehydrogenase forms Lactate
12
What is the primary purpose of anaerobic glycolysis?
Regeneration of NAD+
13
Why must NAD+ be regenerated for glycolysis?
NADH cannot cross the mitochondrial membrane
14
ATP production in glycolysis?
net gain of 2 ATP per a glucose molecule
15
What activates PFK-1?
F-2,6-BP, AMP
16
What inhibits PFK-1?
Citrates, ATP
17
What activates Pyruvate kinase?
F-2,6-BP, AMP
18
What inhibits pyruvate kinase?
Acetyl-CoA, ATP
19
What is 2-3BPG's affect on erythrocytes?
Decreased affinity for O2, so O2 is released
20
What type of carb metabloism is not affected by insulin?
Fructose metabolism
21