Flashcards in Membrane Composition and Structure Deck (22)
Major lipids of the membrane
Phospholipids, Glycosphingolipids, Cholesterol
Detergents are required to separate them from the membrane. Interact w/ only the hydrophobic core of the membrane
Transmembrane Integral Protein Types
α-helical or β-sheets
Do not require detergents to separate them from the membrane. Can interact with lipid component or integral protein.
Where is cardiolipin found?
Mitochondrial membrane only
What kind of fatty acid is oleic acid?
Monounsaturated (medium melting point)
What kind of fatty acid is Linoleum acid?
Polyunsaturated (low melting point)
What kind of fatty acid is Stearic acid?
Saturated (high melting point)
What kind of fatty acid is palmitic acid?
What kind of fatty acid is Arachidonic acid?
What category of lipid does sphingomyelin belong to?
Increasing the amount of cholesterol in a saturated fatty acid rich membrane will do what to the property of the membrane?
Increase fluidity and decrease transition temperature
How will increasing the amount of unsaturated fatty acids in the membrane alter the property of the membrane?
It will increase the fluidity of the membrane
How can polytopic integral membrane proteins affect membrane structure?
It can disrupt membrane thickness
What is the most abundant fatty acid in human tissue?
What are the 3 types of passive transport across a membrane?
Permeability, Simple Diffusion, Facilitated Diffusion
What lipids are primarily found in the outer leaflet?
Phosphatidylcholine (PC) and sphingomyelin
What lipids are primarily found in the inner leaflet?
Phosphatidylserine (PS) and Phosphatidylethanolamine (PE)
What enzymes are responsible for moving phospholipids from one membrane to another?
Translocases and Flipases
What lipid is restricted to the outer leaflet?
Glycoplipids due to the carbohydrate portion
What is one role of cholesterol in relation to plasma membranes?
Modulating fluidity (more=more fluidity below melting point)(if above melting point, will limit the fluidity)