Membrane Composition and Structure Flashcards Preview

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Flashcards in Membrane Composition and Structure Deck (22):
1

Major lipids of the membrane

Phospholipids, Glycosphingolipids, Cholesterol

2

Integral proteins

Detergents are required to separate them from the membrane. Interact w/ only the hydrophobic core of the membrane

3

Transmembrane Integral Protein Types

α-helical or β-sheets

4

Peripheral proteins

Do not require detergents to separate them from the membrane. Can interact with lipid component or integral protein.

5

Where is cardiolipin found?

Mitochondrial membrane only

6

What kind of fatty acid is oleic acid?

Monounsaturated (medium melting point)

7

What kind of fatty acid is Linoleum acid?

Polyunsaturated (low melting point)

8

What kind of fatty acid is Stearic acid?

Saturated (high melting point)

9

What kind of fatty acid is palmitic acid?

Saturated

10

What kind of fatty acid is Arachidonic acid?

Polyunsaturated

11

What category of lipid does sphingomyelin belong to?

Sphingolipid

12

Increasing the amount of cholesterol in a saturated fatty acid rich membrane will do what to the property of the membrane?

Increase fluidity and decrease transition temperature

13

How will increasing the amount of unsaturated fatty acids in the membrane alter the property of the membrane?

It will increase the fluidity of the membrane

14

How can polytopic integral membrane proteins affect membrane structure?

It can disrupt membrane thickness

15

What is the most abundant fatty acid in human tissue?

Oleic Acid

16

What are the 3 types of passive transport across a membrane?

Permeability, Simple Diffusion, Facilitated Diffusion

17

What lipids are primarily found in the outer leaflet?

Phosphatidylcholine (PC) and sphingomyelin

18

What lipids are primarily found in the inner leaflet?

Phosphatidylserine (PS) and Phosphatidylethanolamine (PE)

19

What enzymes are responsible for moving phospholipids from one membrane to another?

Translocases and Flipases

20

What lipid is restricted to the outer leaflet?

Glycoplipids due to the carbohydrate portion

21

What is one role of cholesterol in relation to plasma membranes?

Modulating fluidity (more=more fluidity below melting point)(if above melting point, will limit the fluidity)

22

What are the ratios of ions transported in Na, K, ATPase?

3Na's out of the cell, 2K's into the cell, 1 ATP used