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dr taher classes HK > CVS 17 > Flashcards

CVS 17 Flashcards

(73 cards)

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1
Q

gastroenteritits in cruise ships and daycare

A

norovirus

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2
Q

calcivirus

A

norovirus ICOSAHEDRAL

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3
Q

RNA non enveloped virus

A 
CPRH
Calci
Picorna
Reo
Hep E
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4
Q

Picorna virus includes

A 
PERCH
Polio
Echo
Rhino
Cxsackie
Hep A
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5
Q

NON enveloped DNA

A 
PAPP
Parvo
Adeno
Papilloma
Polyoma
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6
Q

Corona virus

A

common cold SARS

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7
Q

Delta cirus

A

HEP D —- defective virus

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8
Q

how does hep b help hep D

A

helps hep D to invade and replicate
forms the EXTERNAL shell of HEP D
HBsAG forms the coat

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9
Q

two forms of infections by HEP D

A

co infection —- B + D together

Suprainfection — previosuly infected hepatocytes get inf with HEP B

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10
Q

mode of HEP D transmission

A

sexual
perinatal

R/O HCC

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11
Q

which hepatitis virus dont increase risk for HCC

A

HEP A and E

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12
Q

Hepatitis A belongs to

A

Picorna virus — RNA

feco oral route —- shell fish too

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13
Q

shell fish can be linked with

A

hep A
v. cholera
clostridium sepcticum

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14
Q

hep A incubation and risk factors

A 
short 30 days 
travellers 
overcrowded areas/ poor sanitation
endemic regions 
homosexual men
chronic liver disease 
clotting factor disorders
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15
Q

biopsy of hep A liver

A

swelling of hepatocytes
macrophages and lymphocytes (CD8 T cells)
councilman bodies — apoptotic bodies

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16
Q

vaccine for hep a

A

yess

also give immuniglobulins

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17
Q

special about HEP B

A

has a reverse trasncriptase activity

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18
Q

transcriptional activator made by hep B

A 
HBX 
it is a viral protein 
interferes with p53 function
activates synthesis of IGF 1 receptor (proliferation)
and insulin like growth factor 2
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19
Q

early onset of hep b symtoms

A

fever
arthralgia
rash
SERUM SICKNESS

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20
Q

syndromes tha tcan be cuased by HEP B

A

acute Hep b —- cn resolve
chronic hepatitis — with / without cirrhosis
massive liver necrosis —- fulminant hepatitis

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21
Q

Hbs ag

A

acute infection

chronic infection with inc infectivity and also with decreased infectivity

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22
Q

Hbs AB

A

immunized

recovery

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23
Q

HBe ag

A

acute

chronic high infectivity

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24
Q

HBe ab

A

recovery
WINDOW
chronic LOW infectivity

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25
HB c Ab
recovery
26
marker of Hep B infection
surface antigen
27
mother has active hep B | what will be seen in the neonates blood
HB e ag INC viral load can cross placenta these babies are mostly asymptomatic ---- can progress to cirrhosis and HCC
28
txt for neonates with hepb mothers
vaccine can be given immunoglobulins can be given tooo PREVENT CHRONIC INFECTION
29
biopsy of hep B
T CELL CD 8 mediated apoptosis --- ag is presented on teh suface of hepatocytes MHC 1 ground glass app
30
hep B itself has no cytotoxic effect | what has this effect
surface antigen | core antigen
31
chronic viral hepatitis inflammation
mainly targets surrounding area of portal triad hepatic artery portal vein bile ducts
32
how to reduce worldwide cases of HCC
HEP B VACCINE
33
lacks 3'5 exonuclease activity
HEP C proof reading activity --- HC e Ag this is why no vaccine ---- antigenic variation cause envelope antigen is always changing
34
biopsy of hep c shows
macrovesicular STEATOSIS lymphoid aggregates portal tracts PATCHY necrosis
35
Hepatitis E
non enveloped | fulminant hepatitis in pregnant mothers
36
inflammation of LIVER parenchyma can be caused by
EBV CMV HEP
37
Flavivirus
``` HCV dengue yellow st louis encephalitis west nile virus zika virus ```
38
dengue fever symptoms
``` flu like illness myalgia joint pain (break bone fever) RETRO ORBITAL PAIN rash ------ white island in sea of red ```
39
All RNA are single straded EXCEPT
REO virus colitivirus ---- colarado tick fever rotavirus ---- fatal diarrhea
40
All DNA are double stranded EXCEPT
parvo ---- single stranded
41
Dengue hemorrhagic fever
``` thrombocytopenia increased vascular permeabillity increase risk of bleeding SHOCK hypotension ```
42
secondary infection of dengue
usually by a diffff serotype | much more severe course of disease
43
diagnosis of dengue
torniquet test --- cuff inflammation for 5 mins ----- PETECHIA NS1 antigen
44
simultaneous infections with dengue
CHIKUNGUNYA | ZIKA
45
West nile virus grows mostly in
birds and warm climate
46
west nile transmission
aedes mosquito
47
west nile mannifestation
myalgia headache progress --- meningitis / encephalitis neurological deficits flaccid paralysis neurological deficits can be lethal --- stay LONG TERM
48
developing countries --- flaccid paralysis makes u think of
polio
49
which viral infection can show parkinson like features too
west nile
50
arbovirus vector transmits
west nile ( flavi) la cross virus east/west equine (toga) st. louis encephalopathy (flavi)
51
risk factors that lead to west nile infection
malignancy immune supp elderly
52
CSF analysis in West nile virus
lymphocytic pleocytosis
53
YEllow fever reservoir
monkeys | flavivirus
54
mannifestation of flavi
black vomitus jaundice destructive apoptotic bodies ---- councilman bodies
55
zika virus
flavivirus infects FETAL NEURAL PROGENITOR cells severe congenital malformations --- microencephaly, miscarriages, congenital contractures joint cortical thinning
56
transmission, diag and txt for zika
sexual / vertical tx diag ---- RT PCR no txt ---- lethal
57
filo virus
EBOLA targets ENDOTHELIAL cells!! Liver ---- incubation for 3 weeks
58
sympmtoms of ebola
``` flu like myalgia fever vomitting hemorrhagic shock DIC ``` reservoir -- monkey, body fluids
59
how to protect onself from ebola in healthcare env
strict isolation of infected
60
Picorna virus
``` PERCH Polio Echo Rhino Coxsackie Hep A ```
61
Polio
ant horn --- LMN symptoms
62
what type of polio vaccines are there
LIVE ----- sabin --- oral | KILLED ---- salk ----
63
anterior horn can be affected in which conditions
polio West nile virus (flavi) werdng hoffman synd spinal muscular dystrophy
64
Live vaccinations examples
``` strong life long immunity Polio Rotavirus MMR VZV yellow fever influenza (intranasal) small pox typhoid BCG adenovirus ```
65
which live vaccine can be givin in HIV pts
>200 CD4 | MMR and varicella
66
killed vaccine
``` RIPA Rabies Influenza (IM) Polio ( SALK) AHEP A ```
67
what kind of resp induced by killed vac
humoral only ag is present on the extracellular surface so cant elicit a t cell resp prevents viral entry inside cell so cant be presented by APC ---- need boosters
68
sub unit vaccines
``` Ag Hbs Ag HPV (high risk) Str pneumo Nisseria H. influenza ```
69
conjugate vaccine
polysaccharide PLUS PROTEIN --- stronger resposne (T CELL) H.inf N,meningitidis str pneumo
70
toxoid vaccine
diptheria tetanus whooping cough
71
what is a toxoid vaccine
denatured toxin pf bacteria BUT INTACT receptor that can bind to antibodies
72
echovirus
from picronavirus cause aseptic meningitis
73
coxsackie virus
picornavirus

dr taher classes HK (24 decks)

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