cvs23

Question 1

confirmatory test for EBV

Answer 1

EBV nuclear antigen

EBV capsid antigen

Question 2

mononucleosis like syndrome

Answer 2

congenital cmv
saliva
urinary
sexual contact

Question 3

cmv in HIV

Answer 3

CREEP
Colitis
Retinitis
Esophagitis ---- linear ulcers
Encephalitis
Pneumonitis 

most common is retinitis

Question 4

cmv inclusion

Answer 4

intra nuclear owl eyes

Question 5

congenital cmv

Answer 5

choriretinitis (cotton wool exudates)
seizures
paraventricular calcifications
microcephaly
sensorineural deafness

Question 6

HH6/7

Answer 6

Roseola
fever first then maculopapular rash
seizures

rash starts on trunk and spreads to extremities

Question 7

HHV8

Answer 7

kaposci
CD4 <500
appear on feet and legs —- blue brownish dermal palque
can also appear on mucosa — GIT, face and lungs

lungs usually means LATE

Question 8

histo in kaposci

Answer 8

spindle shaped
proliferation of ENDOTHELIUM + inflammation
RBC extravasate
lymphocyte predominance

Question 9

what is kaposi commonly confused with

Answer 9

bartonell henslae
cat scratch
but this will have a stellate GRANULOMA with neutrophilic infilitration (bactera)

Question 10

acyclovir

Answer 10

needs thymidine kinase to be phosphorylated
inibits DNA polymerase
leads to chain termination

Question 11

acyclovir prodrug

Answer 11

valacyclovir

goood bioavailability

Question 12

uses of acyclovir

Answer 12

HSV VZV EBV

Question 13

what is bioavailibility

Answer 13

fraction of the drug that reaches systemic circulationin an unchanged manner

Question 14

high first pass means

Answer 14

low systemic circulation conc

most drug is metabolised

Question 15

bioavailibility formula

Answer 15

Area under curve (po) / AUC (IV)

Question 16

loading dose

Answer 16

VD * Cp / f

Question 17

rltnshp between loading dose and bioavalibility

Answer 17

high bio means low loading dose

Question 18

ECF ICF

Answer 18

ECF = 1/3 = 14
ICF = 2/3 = 28

Question 19

ECF is further divided into

Answer 19

plasma = 3
interstitium = 11

Question 20

wich particals can go into the ICF

Answer 20

small
uncharged 
lipophilic 
hydrophobic 
HIGHEST VOLUME OF D

Question 21

small particles can have —- Vd

Answer 21

highest 42

they can be present in all layers

Question 22

volume of distribution

Answer 22

D / C

Question 23

half life

Answer 23

0.7 * Vd / Clearnce

Question 24

absent hematotoxicity

Answer 24

acyclovir

Question 25

crystalluria

Answer 25

``` SIGMA Sulfa drugs Indinavir Gancyclovir Methotrexate Acyclovir ```

Question 26

agranulocytosis

Answer 26

``` CGMP carbamezapine, colchicine,clozapine gancyclovir---- inhib DNA polymerase methimazole---- inhib TP ptu ------ inhib TP and 5'deoidinase ```

Question 27

seizures side effect of

Answer 27

``` BITE Bupropion / b6 INH / imipenem (cilastatin) Tramadol Enflurane ``` amantadine landanosine gancyclovir foscarnet

Question 28

foscarnet se

Answer 28

seizures nephrotoxic hypo hypercalcemia hypo hyper phosphatemia hypokalemia hypomagnesiema

Question 29

cidofovir

Answer 29

``` DNA P + RNA P no thymidyl kinase required CMV reitinits long t1/2 nephrotoxic ```

Question 30

LEDIPASVIR | OMBITASVIR

Answer 30

NS5A | non structural protein RNA replication

Question 31

SOFOSBUVIR | DASABUVIR

Answer 31

NS5B | chain termination

Question 32

SIMEPREVIR | GRAZOPREVIR

Answer 32

NS3/ 4A | photosensitivity rashhhh

Question 33

ortilstat

Answer 33

pancreatic lipase inhib

Question 34

polygenic inheritence

Answer 34

``` HISTAGE Hypertension Ischemic heart Schizo Type 3 diabetes Androgernic alopecia Glaucoma Epilepsy ```