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dr taher classes HK > CVS 10 > Flashcards

CVS 10 Flashcards

1
Q

XLR disease mnemonic

A 
GOLF CHilD
G6PD
Otc def (orotic aciduria)
Lesch neyhan
Fabry (a galactosidase)
Hunter ( iduronolate)
CGD
D Alas (heme synthesis)
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2
Q

terbinafine mechanism

A

inhibits sq epoxidase

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3
Q

terbinafine used to treat

A

onychomycosis / dermatophyte

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4
Q

terbinafine S.E

A

toxic to liver

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5
Q

Echinocandins

A 
fungins 
cell wall ( b glucan)
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6
Q

echinocandins S.E

A

histamine release

GI upset

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7
Q

mechainsm of Griseofulcin

A

inhibits microtubules

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8
Q

method of administration of Griseofulvin
where does it have its major effect?
idications?

A

orally
keratin areas
tinea / ring worms

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9
Q

Griseofulvin cyp450 enzyme inhibitor or inducer

A

inducer

remmber My New GPRS Cell Phone

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10
Q

side effects of Griseofulvin

A

Disulfram like reactions

flushing tachy hpoTension

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11
Q

drugs that can cause a disulfram like reaction

A 
CGMP
Cefoperazone (3rd), cefotetan (2nd)/ chlorpropamide
Griseofulvin (microtubule)
Metronidazole
Procarbazine ( alkylating agent)
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12
Q

smallest form of cytoskeletal elements

and some examples

A

microfilaments

actin/ microvilli

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13
Q

viementin

A 
intermediate  filament
found in mesenchymal tissue
sarcoma 
RCC
meningioma
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14
Q

GFAP

A

intermediate filament

Glial cells

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15
Q

Desmin

A

intermediate filament
muscle (rhabdomyosarcoma)
ex Tuberous sclerosis

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16
Q

cytokeratin

A

also intermediate filament

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17
Q

largest cytoskeletal element

A

microtubule

movement / cell division

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18
Q

drugs MOA inhibiting microtubule polymerization

A

vincristine vinblastine

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19
Q

MOA inhibting de polymerization

A

paclitaxel

docitaxel

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20
Q

aneterograde transport

A

kinesis (towards +ve side)

Positive in Periphery

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21
Q

retrograde transport

A

dyenin

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22
Q

viruses that use retrograde transp

A

polio
herpes
rabies
tetanus

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23
Q

what is the DOC for herpetic neuralgia

A

gabapentin

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24
Q

drugs that inhibit microtubule formation

A

Griseofulvin
bendazoles
colchicine

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25
Kartagener mode of inheritnce whats the defect signs symp
``` AR dyenin arm primary ciliary dyskinesia recurrent sinusitis/ situs invertus/ bronchiectasis ectopic pregnancy ```
26
screening test for cystic fibrosis and primary ciliary dysk
nitric oxide test
27
what is required for synchronous contraction of heart uterus osteocytes etc
gap junction
28
failure of phagosome to fuse with lysosome
chediak hegashi
29
symp of chediak higashi | and the gene
``` PLAIN Progressive neurodegeneration Lymphohystiocytosis Albinism Neuropathy ``` gene LYST
30
budding yeast at 20 degrees | germ tubes at 37
Candida
31
Candida has true hyphae or pseudihyphae
both | pseudohyphae at germ tubes 37 degrees
32
who is at risk for candida inf
babies immunocomp HIV diabetics
33
typical infection in baby linked to candida ? | and in females?
diaper rash | vulvovaginitis
34
txt for candida
flucanazole nystatin fungins ampho b
35
branch septate hyphae at 45 degrees | V shape
aspergillus
36
what is the form of aspergillus
MOLD form not dimorphic
37
aspergilloma can be formed in what conditions
pre existing cavitary lesions in TB for exmp air crescent sign aflatoxin
38
invasive aspergillosis
Neutrophils low Immunocomp HIV CGD
39
aflatoxin can cause
HCC | alcohol
40
afltoxin found in
aspergillus stored grains nuts causes HCC
41
Arsenic
smelting of metals/ vineyards | angiosarcoma
42
cigarette smoke
``` has PAH lung cancer (sq, small cell, large cell) bladder canc ( sq and transitional) esophageal (adeno lower eso, sq upper 2/3 eso) RCC ```
43
relative vitamin A def caused by
cigarette smoke and it leads to pancreatic cancer cervical sq laryngeal carcinoma
44
aljylating agents can cause
leukemia and lymphoma
45
Napthylamine
transitional cell carc
46
HPV
16 18 31 33 | cervical penil head and neck cancer
47
HTLV 1
adult t cell leukemia/ lymphoma
48
HTLV 1 belongs to whch virus class
retrovirus like HIV
49
EBV herpes 4
hodgkin non hodgkin nasopharyngeal ca (chinese) primary CNS lymphoma (<100 cd4)
50
EBV in endemic areas can cause
``` burkitt lymphoma 8,14 transloc extranodal mass = jaw (african) abdomen (sporadic) ```
51
EBV in transplant pt
lymphoprolif disease
52
schistosoma hematobium
squamous cell carcinoma of bladder
53
chlonorchis sinensis
liver fluke | cholangiocarcinoma
54
H pylori
intestinal type gastric carcinoma | MALTOMA (11,18)
55
inflammation MALTOMA can be caused by or seen in
H pylori sjogern hashimoto
56
type 1 hypersensitivity response assoc with asthma Cystic Fibrosis may cause bronchiectasis and eosinophilia
Allergic bronchopulomonary aspergillosis
57
encapsulated yeast | pigeon droppings
cryptococcus neof
58
dissemination route for cryptococcus
hematogenous spread
59
cryptococcus meningitis appearance
soap bubble
60
what is the special test for cryptococcus | also the ink?
latex particle agglutination | india ink
61
how to stain the capsule for cryptococcus
mucicarmine stain | RED capsular inner core
62
mold form only | broad 90 degrees non septate
mucor rhizophus
63
how is mucor contracted
inhaled --- prolif in bloooood vessels ---- penetrate through cribriform plate and into inus
64
most common cause of cavernous sinus thrombosis
STAPH AUR strept mucor
65
drainage of cavernous sinus
sup petrosal sinus ---- great verebral vein pf gallen | inf petrosal sinus ---- int jugular vein
66
3rd cranial nerve palsy
down n out
67
corneal senation
V1 sensory | 7 is motor (reflex)

dr taher classes HK (24 decks)

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