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dr taher classes HK > cvs19 > Flashcards

cvs19 Flashcards

1
Q

rhabdo virus

A

bullet shaped

rabies (helical)

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2
Q

transmission of rabies

A 
mostly bats 
fox
skunk
dogs
racoons
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3
Q

other diseases spread by bats

A

Histoplasma
Eebola
Rabies

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4
Q

what type of inclusion bodies seen in rabies

A

CYTOPLASMIC negri bodies

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5
Q

where do RNA viruses replicate

A

most in cytoplasm EXCEPT
influenza and retro

Replicates Inside nucleus ( R I )

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6
Q

DNA viruses replicate

A

in nucleus EXCEPT POX

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7
Q

rabies mannifestations

A 
hydrophobia 
aerophobia --- spasm of pharynx
agitation / anxiety
fever
malaise
myalgia
spasticity
autonomic instability
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8
Q

Asc flaccid paralysis

A

rabies and guillane bare

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9
Q

desc flaccid paralysis

A

polio
diptheria
botulinism

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10
Q

desc spastic paralysis

A

tetanus —- inhbition of glycine release

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11
Q

prognosis of rabies

A

resp depression failure and death

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12
Q

how does the virus enter body

A

enters neurons —- peripheral neurons —- dorsal root ganglion — ascends — replicates in brain

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13
Q

retrograde transport within neuron by

A

DYENIN

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14
Q

prophylactic vaccine for rabies given to

A

cave explorers
vets
labs (infected tissue)
ppl travelling to devlpng countries — DOGS

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15
Q

beta proriolactone

A

used for culturing rabies vaccination

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16
Q

retroviruses

A

HTLV1

HIV

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17
Q

HTLV1

A

adult t cell leukemia
lymphoma

mature CD4 T cells

Japanese/ caribbean/ west africa

skin lymhnodes bones (lytic bone lesions)
hepatosplenomegaly

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18
Q

what is the function of IL 1 interms of bone

A

increases osteoclas activating factor

HYPRCALCEMIA

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19
Q

mycosis fungoides sezary syndrome

A

mature CD4 t cells
skin cutaneous T CELL LYMPHOMA

cancer cells aggrregate within epidermis —– intra epidermal aggregates of neoplastic cells

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20
Q

how does sezary sydnrome devlop

A

cancer cells within epidermis form micro abcess —- disseminate through blood —- t cell leukemia

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21
Q

HIV

A

replicates inside nucleus

polycystronic mRNA — 40 different types of proteins made

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22
Q

HIV makes multiple different types of proteins by which process

A

alternative splicing

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23
Q

gag gene

A

capsid —- protein coat

matrix

24
Q

env gene

A

envelope glycoprotein gp 160

25
gp 160 is broken down in
ER golgi ----- 120 and 41
26
pol gene
reverse transcriptase aspartate proteinase integrase
27
CCR5 vs CCR4
CCR5 --- presented by macrophages early | CXR4 --- T cell late
28
what glycoproetin is used for attachment
Gp 120
29
fusion and entry
gp 41 | chemokine associated receptor
30
nucleoside RTI
``` LADZ Lamivudine Abacavir Didanosine Zidovudine ```
31
CCR5 CXCR4 needed for
ENTRY
32
what happens in HIV 2 infections
low levels of viral count low risk of transmission longer asymptomatic phase
33
CCR5 homozygous mutation vs heterozygous
homo --- immunity | hetero --- slower onset of disease
34
investigation for HIV
Ab immuno assay test detects the capsid p24 ( made by gag gene) increaesed sens + specificity
35
what to do in case the immunoassay is negative
intermediate acute infection could be possible NAT HIV1 required
36
can u do immunoassay for neonates
NO wont detect antibodies | do RT PCR
37
treatment for HIV
2 NRTI + integrase inhibitor
38
zidovudine needs to be ----- before it can function
phosphorylated | sometimes can also be incorp into genome ---- chain termination!!
39
how is resitance to zidocudine dvpd
pol gene mutation rmmbe rpol gene ---- trasncriptase
40
how to decrease vertical transmission from mother to babies
zidovudine | nevirapine single dose can be given too
41
SE of zidovudine
``` BONE MARROW supp myalgia myopathy lactic acidosis peripheral neuropathy ```
42
how to treat bone marrow supp
G CSF ---- filgrastim (for low wbc count) GM CSF----sargramostim (for low wbc count) erythropoitin darbopoitin
43
thrombopoitin
ELTROMBOPAG---- -TPO rec agonist ROMIPLASTIM ---- TPO analog OPRELVEKIN ---- IL 11
44
Aldesleukin
IL1 | RCC and metastatic melanoma
45
Lamivudine SE
LEAST TOXIC | active in HEP B
46
Abacavir
allergy hypersensitivity HLA B5701 mutation
47
Didanosine
PANCREATITIS / peripheral neuropathy
48
dizoxide
decrease insulin production by opening K channels
49
NNRTI
Dalaveridine Efavirenz Nevirapine
50
vivid dreams or dysphoric dreams are caused by
efavirenz
51
visual brightness increased by
IVABRIDINE BR ---bradycardia I---- eye
52
protease inhibtors
AVIRS
53
increase creatinine kinas e
TEGRAVIRS
54
allergic reaction at site of injection
enfuuuviritide
55
drugs that cause crystalluria
``` SIGMA Sulfa Indinavir Gancyclovir Methotrexate Acyclovir ```

dr taher classes HK (24 decks)

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