Flashcards in Endo p. 322-326 Deck (47)
Which adrenal insuff. spares the skin and mucosa? and why?
Tertiary and Secondary, because there is a decr in ACTH production --> less MSH by product
What is the MC tumor of the adrenal medulla in children?
Classic histology presentation of Neuroblastoma:
Homer-Wright rosett and small, round, blue/purple nuclei
Name 2 paths derived from neural crest?
Homovanillic acid (HVA) a breakdown product of?
---- is a breakdown product of norepinephrine.
vanillylmandelic acid (VMA)
“dancing eyes-dancing feet” are seen in?
Neuroblastoma, Subacute screlosing P.
Name episodic hyperadrenergic symptomsof pheochromocytoma (5 P’s):
Pressure (incr BP)
T or F? Wilms tumor can cross the midline vs. Neuroblastoma which is smooth and unilateral.
F. its the opposite
Why is α-blockade administred in Pheochromocytoma
before giving β-blockers prior to tumor resection?
to avoid a hypertensive crisis.
What % causes calcification in pheochromocytoma?
Neuroblastoma has an overexpression of which onco-gene?
What is a typical histology of Pheochomocytoma?
enlarged pleomorphic nuclei, typical of malignancy.
2 tumor markers for Neroblastoma?
Bombesin and neuron-specific enolase ⊕.
Name one phath that use Bombesin and neuron-specific enolase as tumor markers?
lung cancer (bronchial carcinoid)
3 Paths associated with Pheochomocytoma?
neurofibromatosis type 1,
von Hippel-Lindau disease,
MEN 2A and 2B.