Endo p. 322-326 Flashcards Preview

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Flashcards in Endo p. 322-326 Deck (47)
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31

Which adrenal insuff. spares the skin and mucosa? and why?

Tertiary and Secondary, because there is a decr in ACTH production --> less MSH by product

32

What is the MC tumor of the adrenal medulla in children?

Neuroblastoma

33

Classic histology presentation of Neuroblastoma:

Homer-Wright rosett and small, round, blue/purple nuclei

34

Name 2 paths derived from neural crest?

Neuroblastoma, Pheochromocytoma

35

Homovanillic acid (HVA) a breakdown product of?

dopamine

36

---- is a breakdown product of norepinephrine.

vanillylmandelic acid (VMA)

37

“dancing eyes-dancing feet” are seen in?

Neuroblastoma, Subacute screlosing P.

38

Name episodic hyperadrenergic symptomsof pheochromocytoma (5 P’s):

Pressure (incr BP)
Pain (headache)
Perspiration
Palpitations (tachycardia)
Pallor

39

T or F? Wilms tumor can cross the midline vs. Neuroblastoma which is smooth and unilateral.

F. its the opposite

40

Why is α-blockade administred in Pheochromocytoma
before giving β-blockers prior to tumor resection?

to avoid a hypertensive crisis.

41

What % causes calcification in pheochromocytoma?

10% calcify

42

Neuroblastoma has an overexpression of which onco-gene?

N-myc oncogene

43

What is a typical histology of Pheochomocytoma?

enlarged pleomorphic nuclei, typical of malignancy.

44

2 tumor markers for Neroblastoma?

Bombesin and neuron-specific enolase ⊕.

45

Name one phath that use Bombesin and neuron-specific enolase as tumor markers?

lung cancer (bronchial carcinoid)

46

3 Paths associated with Pheochomocytoma?

neurofibromatosis type 1,
von Hippel-Lindau disease,
MEN 2A and 2B.

47

Urine and plasma findings is Pheochromocytoma?

 catecholamines and metanephrines in urine and plasma.