Endocrine control of Growth Flashcards Preview

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Flashcards in Endocrine control of Growth Deck (28):
1

Phases of growth

-fetal
-postnatal
-pubertal
- Adulthood
- Senescent

2

Compensatory growth

if you lose a kidney the other one hypertrophies until it can make up for the loss.

3

Catch-up growth

kid with illness has slow growth, once healed....catches up to normal growth rate

4

psychosocial deprivation

kid is in a home where no one likes him...growth slows....decrease caused by low growth hormone production

5

Growth hormone changes height by what percentage?

20-30%

6

Excess growth hormone leads to

Gigantism...height procedes to maximal genetic potential

7

Growth hormone deficiency

Dwarfism

8

KNOW TABLE 3: Effects of hormonal excess or deficiency on growth and development

ok

9

Excess and deficient growth hormone on skeletal maturation?

Normal in excess. Delayed in deficiency

10

Thyroid deficiency on skeletal maturation

delayed

11

Cortisol excess on skeletal maturation

delayed

12

Somatotropin

GH

13

Somatomedin

Mediates some GH actions, particularly on bone elongation and adipocytes, also known as IGF-1

14

Somatostatin

hypothalamic peptide that prevents GH secretion

15

Somatocrinin

hypothalamic peptide that stimulates GH...GHRH

16

WHat are the two structures of GH?

22k form . this promotes growth and other metabolic actions

20k: only growth promoting

17

Hyposomatotrophic dwarfism

Purely a GH deficiency

18

Panhypopituitarism?

Lacking all of the pit hormones

19

Major actions of GH on: Body mass

Increases it in the juvenile and pubertal periods

20

GH on tallness:

Increases it during juvenile and pubertal periods

21

Gh contributes to bone thickening which means that if GH goes unregulated you can get

acromegaly

22

GH on fat metabolism?

inc in lipolysis, seen as an increase in FFA

23

GH on carbohydrate metabolism

mildly impairs glucose uptake and utilization

24

Somatomedin (IGF-1) hypothesis KNOW

GH acts on liver ---> IGF-1 secreted---> long bones--> growth

25

Dual Effector Hypothesis KNOW

GH--> bones, muscle, adipose tissue etc..(DIRECT)

GH---> liver---> hepatic effects--> IGHF-1 incr

26

What effect does T3 have on GH function

It enhances it by:
- increasing sensitivity to GH-RH
- Increasing synthesis
- Increasing Responsiveness

27

Cortisone on GH

Depletes the effect of GH

28

What is the best way to measure a person's GH since it waxes and wanes?

IGF-1! KNOW THIS