Glucocorticod drugs Flashcards Preview

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Flashcards in Glucocorticod drugs Deck (14):
1

All hormones made in the adrenal are synthesized from

cholesterol...they are steroids

2

ACTH overproduction causes

Cushings

3

ACTH is synthesized as a part of POMC which also contains MSH.

ok

4

What stimulates ACTH release

CRH

5

Corticotrophic releasing hormone secretion is increased in response to what

STRESS, inflammation, hypoglycemia.

6

CRH is normally released 2 hrs before waking daily

ok

7

What would you want to use to see if cortisol is reacting to ACTH properly?

ACTH preferably. But you don't have that so you use an ACTH analog cosynotropin.

8

What is the deal with corticosteroids and permissiveness?

Corticosteroids increase the effect of epinephrine on lipolysis by increasing protein synthesis

9

Remember, Cortisol and aldosterone both have affinity for the MRs in the kidney that upregulat NaKatpas, Enac, Romk, and SGK1...but what converts cortisol into ------- which has a lower affinity

11 Beta- HYDROXYSTEROID DEHYROGENASE converts cortisol into cortisone

10

Why does Addison's disease = fatigue

levels of cortisol are required for muscle function

11

Admin of Gluccocorticoids

oral

12

Adverse effects

Osteoporosis, Diabetes, Peptic Ulcers, CNS effects, Small testicles from low testosterone (this is from negative feedback), women (anovulation, dysmenorrhea, uterine bleeding) kids (deceased linear growth from GH/IGF1 inhibition)

13

Hydrocortisone

short acting. cortisol equivalent. Adrenal Insufficiency. Addison's

14

Cortisone

short acting, oral. .8% potency/Na retention