Glucocorticod drugs Flashcards
(14 cards)
All hormones made in the adrenal are synthesized from
cholesterol…they are steroids
ACTH overproduction causes
Cushings
ACTH is synthesized as a part of POMC which also contains MSH.
ok
What stimulates ACTH release
CRH
Corticotrophic releasing hormone secretion is increased in response to what
STRESS, inflammation, hypoglycemia.
CRH is normally released 2 hrs before waking daily
ok
What would you want to use to see if cortisol is reacting to ACTH properly?
ACTH preferably. But you don’t have that so you use an ACTH analog cosynotropin.
What is the deal with corticosteroids and permissiveness?
Corticosteroids increase the effect of epinephrine on lipolysis by increasing protein synthesis
Remember, Cortisol and aldosterone both have affinity for the MRs in the kidney that upregulat NaKatpas, Enac, Romk, and SGK1…but what converts cortisol into ——- which has a lower affinity
11 Beta- HYDROXYSTEROID DEHYROGENASE converts cortisol into cortisone
Why does Addison’s disease = fatigue
levels of cortisol are required for muscle function
Admin of Gluccocorticoids
oral
Adverse effects
Osteoporosis, Diabetes, Peptic Ulcers, CNS effects, Small testicles from low testosterone (this is from negative feedback), women (anovulation, dysmenorrhea, uterine bleeding) kids (deceased linear growth from GH/IGF1 inhibition)
Hydrocortisone
short acting. cortisol equivalent. Adrenal Insufficiency. Addison’s
Cortisone
short acting, oral. .8% potency/Na retention
