Thyroid Disorders Flashcards Preview

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Flashcards in Thyroid Disorders Deck (23):
1

What is the test of choice to screen for abnormal thyroid function?

TSH

2

THyroid hormone effects

- Fetal development
- Oxygen consumption and heat production
- CV effects
- Sympathetic effects
- Pulmonary effects
- GI effects
- Skeletal effects
- Lipid and carbs
- Endocrine effects

KNOW THE CHART YOU MADE

3

Symptoms of hypothyroidism

- Fatigue, weakness
- Dry Skin
- Feeling Cold
- Hair Loss
- Memory
- Constipation
- Wt gain with poor appetite
- Menorhaggia--long periods
(Think of Leslie)

4

Signs of hypothyroidism

- Dry skin
- Puffy face
- allopecia
- bradycardia
- carpal tunnel
- serous effusions
- delayed tendon reflex

5

Signs and symptoms of hyperthyroidism

know

6

Know the signs and symptoms of both hypo and hyper

ok

7

Inappropriate TSH levels are generally caused by what in hyperthyroidism

- TSH secreting pituitary adenoma (Remember TSH comes from the pituitary and TRH comes from the Hypothalamus)
- isolated pituitary resistance to thyroid hormone (prevents it from recognizing that levels are high in the bloodstream)

8

TSH levels are generally caused by what in hypothyroidism?

Central hypothyroidism

9

Inappropriate TSH levels when there is no thyroid problem is usually caused by

- systemic illlness
- generalized resistance to thyroid hormone
- assay interference

10

Adding Pathoma Notes to this:

ok

11

How does the Thyroid descend?

Thyroid starts at the base of the tongue and then travels along the thyroglossal duct to the anterior neck. Thyroglossal duct usually goes away, if it doesn/t you may get a thyroglossal duct cyst which just presents as an ANTERIOR NECK MASS

12

Most common ectopic thyroid location

Persistence of the thyroid at the base of the tongue

13

How does Hyperthyroidism increase Basal Metabolic Rate?

Increased synthesis of Na/K ATPase

14

Increased sympathetic nervous system activity due to what?

Increases Beta 1 adrenergic receptor

15

Hyperthyroidism Clinical Pres

WHAT DO The Happy Hefty Sluts Bring for Dinner
W-weight loss
H-heat intolerance
Arrhythmia
T- tacchycardia
D- Diarrhea
O- Oligomenorrhea
T- tremor, anxiety, insomnia
H- HYPOCHOLESTEROLEMIA
H- Hyperglycemia
S- staring gaze/lid lag
B-Bone resorption (osteoporosis risk)
D- Decreased muscle mass

16

Most common cause of hyperthyroidism

Graves Disease

17

Graves disease is

autoanitbody that stimulates TSH receptor in the THyroid (Type II Hypersensitivity)

18

Graves is most common in what sex?

Females

19

Clinical features of graves disease

hyperthyroidism of course
Diffuse goiter- constant TSH stimulation leads to Thyroid Hyperplasia and hypertrophy
Exopthalmos and Pretibial myxedema

20

Whats the deal with exopthalmos and pretibial myxedema,

Fibroblasts overlying the shin and behind the orbit express TSH receptors

21

TSH activation results in glycosaminoglycan buildup , inflammation and fibrosis leading to the exopthalmos and pretibial myxedema/

ok

22

What are glycosaminoglycans?

Chondroitin Sulfate and Hyaluronic Acid.

23

Lab findings in Graves disease?

High total and free T4. (Free T4 downregulates TRH receptors in the anterior pituitary. )
-Low Cholesterol
- Increased serum Glucose