Flashcards in Endo Pharm Deck (22):
1
Prolactinoma causes what clinical signs and symptoms
Women: amenorrhea, infertility, galactorrhea
Men: Infertility, loss of libido, impotence
2
What are the dopamine receptor agonists used to treat Prolactin excess
Bromocriptine: poorly tolerated D2 receptor agonist
Cabergoline: High affinity D2 receptor agonist
3
How do you test for GH deficiency?
With insulin. GH release is stimulated by hypoglycemia. Give insulin to drive down blood sugar and see if GH rises.
4
Human Growth Hormone treatment in kids is most effective in what time period?
First two years. Treat until growth stops
5
Generic hGH is
Somatotropin
6
Somatrem is what
GH with additional methionin
7
Semorelin Acetate?
first 29 aa of hGHRH
8
Adverse effects of Grwoth hormone replacement in kids
Intracranial HTN, papilledema, visual problems, Leukemia
9
Leading cause of retardation worldwide is?
Hypothyroidism
10
Thyroid hormone has what effect on oxygen consumption?
Increases it
11
Thyroid has what effect on CV system
upregulates Beta1 receptors on the heart. Increased HR and strength of contraction (inotrophy)
12
Describe the pathophysiology of Iodine deficiency
Iodine deficiency results in low productin of thyroid hormones. TSH levels increase to try to correct this and you get hypertrophy of the thyroid gland
13
Treat iodine deficiency with
iodized salt
14
How do you treat hypothyroidism
replacement therapy
15
Levothyroxine
L-T4...levFOthyroxine
16
Liothyronine sodium
L-T3
17
Liotrix
mixture of T4 and T3
18
Treat hyperthyroidism with what type of drugs?
Thioureylenes (they inhibit thyroid peroxidase, the enzyme responsible for virtually all of thyroid synthesis)
19
PTU= Propylthiouracil
Inhibits thyroid peroxidase, but also inhibits thyronine 5' deiodinase (5'/3' deiodinase which is responsible for T4 to T3 conversion).
20
Which hyperthyroid drug is preferred in pregnant patients
polythiouracil. less placental/ milk transfer
21
AE's of polythiouracil
rash and agranulocytosis
22