Flashcards in Endo Pharm Deck (22):
Prolactinoma causes what clinical signs and symptoms
Women: amenorrhea, infertility, galactorrhea
Men: Infertility, loss of libido, impotence
What are the dopamine receptor agonists used to treat Prolactin excess
Bromocriptine: poorly tolerated D2 receptor agonist
Cabergoline: High affinity D2 receptor agonist
How do you test for GH deficiency?
With insulin. GH release is stimulated by hypoglycemia. Give insulin to drive down blood sugar and see if GH rises.
Human Growth Hormone treatment in kids is most effective in what time period?
First two years. Treat until growth stops
Generic hGH is
Somatrem is what
GH with additional methionin
first 29 aa of hGHRH
Adverse effects of Grwoth hormone replacement in kids
Intracranial HTN, papilledema, visual problems, Leukemia
Leading cause of retardation worldwide is?
Thyroid hormone has what effect on oxygen consumption?
Thyroid has what effect on CV system
upregulates Beta1 receptors on the heart. Increased HR and strength of contraction (inotrophy)
Describe the pathophysiology of Iodine deficiency
Iodine deficiency results in low productin of thyroid hormones. TSH levels increase to try to correct this and you get hypertrophy of the thyroid gland
Treat iodine deficiency with
How do you treat hypothyroidism
mixture of T4 and T3
Treat hyperthyroidism with what type of drugs?
Thioureylenes (they inhibit thyroid peroxidase, the enzyme responsible for virtually all of thyroid synthesis)
Inhibits thyroid peroxidase, but also inhibits thyronine 5' deiodinase (5'/3' deiodinase which is responsible for T4 to T3 conversion).
Which hyperthyroid drug is preferred in pregnant patients
polythiouracil. less placental/ milk transfer
AE's of polythiouracil
rash and agranulocytosis