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Flashcards in Endo Pharm Deck (22):
1

Prolactinoma causes what clinical signs and symptoms

Women: amenorrhea, infertility, galactorrhea
Men: Infertility, loss of libido, impotence

2

What are the dopamine receptor agonists used to treat Prolactin excess

Bromocriptine: poorly tolerated D2 receptor agonist
Cabergoline: High affinity D2 receptor agonist

3

How do you test for GH deficiency?

With insulin. GH release is stimulated by hypoglycemia. Give insulin to drive down blood sugar and see if GH rises.

4

Human Growth Hormone treatment in kids is most effective in what time period?

First two years. Treat until growth stops

5

Generic hGH is

Somatotropin

6

Somatrem is what

GH with additional methionin

7

Semorelin Acetate?

first 29 aa of hGHRH

8

Adverse effects of Grwoth hormone replacement in kids

Intracranial HTN, papilledema, visual problems, Leukemia

9

Leading cause of retardation worldwide is?

Hypothyroidism

10

Thyroid hormone has what effect on oxygen consumption?

Increases it

11

Thyroid has what effect on CV system

upregulates Beta1 receptors on the heart. Increased HR and strength of contraction (inotrophy)

12

Describe the pathophysiology of Iodine deficiency

Iodine deficiency results in low productin of thyroid hormones. TSH levels increase to try to correct this and you get hypertrophy of the thyroid gland

13

Treat iodine deficiency with

iodized salt

14

How do you treat hypothyroidism

replacement therapy

15

Levothyroxine

L-T4...levFOthyroxine

16

Liothyronine sodium

L-T3

17

Liotrix

mixture of T4 and T3

18

Treat hyperthyroidism with what type of drugs?

Thioureylenes (they inhibit thyroid peroxidase, the enzyme responsible for virtually all of thyroid synthesis)

19

PTU= Propylthiouracil

Inhibits thyroid peroxidase, but also inhibits thyronine 5' deiodinase (5'/3' deiodinase which is responsible for T4 to T3 conversion).

20

Which hyperthyroid drug is preferred in pregnant patients

polythiouracil. less placental/ milk transfer

21

AE's of polythiouracil

rash and agranulocytosis

22

Methimazole?

way more potent than polythiouracil and longer half life. Crosses placenta and gets concentrated in fetal thyroid