Obesity and Regulation of Appetitie Flashcards Preview

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Flashcards in Obesity and Regulation of Appetitie Deck (31):
1

What does BMI equal?

weight(kg)/height (m^2)

2

Obesity equals?

BMI over 30

3

Overwt BMI=

25-29

4

High risk waist circumference in men? Women

Men= over 40
Women over 35

5

What goes up about 5 minutes before hunger hits

Ghrelin

6

What is the endocannabanoid system

Endogenous signaling system. Consists of two types of receptors CB1 and CB2. Generally silent but becomes active in order to reduce pain and anxiety, modulate body temp, inhibit motor behavior, extinguish aversive memories, induce appetite

7

Normal BMI=

25 or lower
25-30= overwt
30-35= obese
35 and up= morbidly obese

8

What are the two components to determining obesity

BMI and waist cuircumference. Visceral fat in the abdomen is very dangerous.

9

Fat is stored as

Triglycerides. KNOW THIS!!! STORED FAT IS TRIGLYCERIDES. Storing fat is not a terrible thing. When we store fat, we are bringing down FFA from the plasma.

10

Visceral fat puts out more toxic products than other fat stores. Toxic products like

cytokines, c-reactive protein, TNF-alpha

11

What is the only good thing that comes out of fat cells

Adiponectin....and less of it comes out the more overwt you get

12

What are the three components that make up energy expenditure

Physical activity, thermic effect of food, Basal metabolic rate.

13

What is the most important of these three

Basal Metaboloic Rate

14

NEAT

Non-excercise activity thermogenesis. Can be calculated by figuring out thermal energy of food and the BMR and subtracting NEAT from it

The other option is to estimate activities

15

What part of the hypothalamus expresses receptors for the hormones and neuropeptides that regulate feeding?

Arcuate nucleus

16

What is the major site of TRH and CRH synthesis in the hypothalamus?

Paraventricular nucleus

17

The para ventricular nucleus, obviously would want to receive signals from teh ARC in order to better judge when TRH and CRH would need to be released

ok

18

Neropeptide Y, Aghouti related Proteins (AgRP), and hypocretin/oxerins stimulate what?

Food intake

19

In rats, NPY stimulated food uptake for a short period, AgRP for longer periods

ok

20

The Endocannabanoid system

Generally silent but becomes active to decrease pain and anxiety, abolish bad memories, regulate body temperature, hormone release and smooth muscle tone, inhibit motor activity, induce appetite

21

Which ECS receptors are involved in appetite

CB1

22

Overactive ECS leads to what three things

1) increased appetite
2) increased motivation to eat
3) increased fat storage.

Its a feed forward system. The more you eat the more active it becomes

23

The hypothalamic anorexigenic agents include the melanocortins, cocaine-and-amphetamine regulated transcript (CART), and serotonin.

KNOW

24

Leptin seems to promote not eating

ok

25

Congenital leptin deficiency leads to

Severe childhood obesity

26

Leptin deficiency occurs when what is deleted

guanine in codon 133

27

MC4 receptor dediciency also leads to obesity

ok

28

KNOW THE CHART YOU MADE

ok

29

Hypertension, dyslipidemia, T2D

These comormidities increase as BMI increases. BMI over 27 is bad news.

30

. Virtually all of the peripheral signals (e.g., insulin, PYY, leptin, CCK) are triggered by food ingestion and attenuated by fasting or starvation, indicating a response system that is tailored at satiety and meal termination

important conclusion. Most hormonal actions are post prandial.

31

Ghrelin, the only peripheral signal activated preprandially, may be unique in its role as a rare peripheral signal for hunger and meal initiation.

Ghrelin is unique in that it rises before meals.