Testicular Disease Flashcards Preview

Endocrinology > Testicular Disease > Flashcards

Flashcards in Testicular Disease Deck (26):
1

Testicular peptide hormones are

Follistatin, activins, inhibins

2

What does follistatin do?

Inactivates both activins and inhibins

3

Activins are produced where and do what?

Sertoli cells, stimulate FSH beta0-subunit production

4

Inhibins?

Produced in the seminiferous tubules, suppress FSH

5

What happens if the seminiferous tubules are injured?

FSH goes up

6

Hypothalamic dysfunction

low GnRH leads to low LH and FSH

7

Pituitary disorders

Low LH and or FSH production

8

Gonadal disorders

failure of testosterone production from Leydig Cells and/or spermatogenesis. LH and FSH will be elevated if there is no feedback

9

Post gonadal disorder

defects in testosterone receptor function

10

Normal LH and FSH in the face of low T +

pathologic

11

Fertile Eunuch syndrome =

LH deficiency

12

What happens if you are LH deficient?

no T

13

Hyperprolactinemia

Prolactin drives down GnRH so no LH and FSH

14

Hemochromatosis

iron in pituitary and testes

15

Klinefelter's syndrome

xxy, tall, gynecomastia, eunuchoid, Mental retardation

16

body never exposed to testosterone

no secondary sex characteristics

17

Pre-pubertal gonadal failure

small dick, balls, prostate
delayed puberty
long arms and legs
reduced musculaturehigh pitched voice

18

post pubertal

progressive decrease in muscle mass
loss of libido
impotence
infertilitypoor ability to concentrate
hot flashes

19

LH and FSH are released in what fashion

pulsatile

20

If you dont release LH and FSH in a pulsatile fashion they have the opposite effect

truth

21

What's weird about prolactin

It is always being made unless dopaminergic signaling tells it to stop

22

What does prolactin do to LH and FSH

turns it off

23

What is Kollman's syndrome?

failure to enter puberty and anosmia (can't smell). Normal LH and FSH with low T

24

Prader willi

Hyperphagia with obesity, micropenis, small hands and feet

25

Lawrence Moon

Retinitis Pigementosa and polydactyly

26

Soft testes? Haven't seen LH and FSH in a while

ok