Diabetes Drugs Flashcards Preview

Endocrinology > Diabetes Drugs > Flashcards

Flashcards in Diabetes Drugs Deck (28):
1

Stimulants of insulin release

increase in blood glucose, AA, vagal stimulation, sulfonyl ureas

2

Amplifiers of release

Gastric hormones and adrenergic stimulation

3

Inhibitors of insulin

Somatostatin, drugs, catecholamines

4

Acarbose is what?

Alpha-glucosidase inhibitors

5

Porcine insulin is how many Amino Acids different than human

1

6

Bovine and Ovine is how many amino acids different?

3

7

Short acting insulin

rapid onset of action, short half life, intermediate, long acting

8

Short acting insulin, called regular insulin, is the only type that can be given IV

ok

9

Insulin is injected twice daily, Called Lente insulin (30% short and 70% long acting zinc insulin crystals)

ok

10

Insulin demetir

Isoelectric point has been modified to increase half life. Has a twice daily dosing with low peak insulin concentration that decreases chance of nocturnal hypoglycemia. Forms a precipitate.

11

Insulin Glargine

Like Insulin Demetir

12

Metformin

Decreases hepatic gluconeogenesis, Doesn;t affect insulin secretion at all. Used in type 2. Oral no metab. BELONGS TO THE BIGUANIDE CLASS

13

Repaglinide

Benzoic acid derivative. Increases insulin secretion, Rapid GI absorption. Taken before meals to control post-prandial Blood glucose

14

Pioglytizone

GLUT 4 GOES UP. Increases insulin sensitivity by increaseing glucose uptake to tissues.

15

Pioglytizone binds to what

Peroxisome Proliferator- Activator Receptor

16

Acarbose

Its an alpha glucosidase inhibitor. Reduce intestinal absorption of starch and disaccharides by inhibiting brush border alpha glucosidase. Reduces post-prandial glucose glucose elevation. DONT USE ALONE

17

Colesevelam

bile acid sequestrant. Lowers cholesterol. Useful in Type 2 Diabetes Mellitus pts who are taking other meds. Interrupts enterohepatic cycling

18

Exanatide GLP-1 agonist

Know that shit

19

Increase in GLUT-4, increase in insulin uptake into tissues?

PIOGLOTIZINE

20

Increases insulin secretion. Used pre-prandially. Has Rapid GI absorption

Repaglinide

21

Semilente

short acting, longer half life

22

sitagliptin

inhibits enzymes that degrade incretins. These enzymes are called dipeptyl-peptidase 4, therefore sitagliptin is a dipeptidyl peptidase 4 inhibitor.

23

What are incretins

things that raise insulin secretion.

24

The major incretin we talked about

GLP-1....secreted by endothelial cells in the epithelium of the small intestine

25

Why is there no risk of hypoglycemia in a pt taking metformin

It does virtually nothing to insulin secretion.

26

Major drug on our list for increasing insulin sensitivity?

Pioglitazone...Binds PPARy and increases GLUT 4 transport of glucose into tissues (this is the mechanism by which insulin works)

27

Which Diabetes drug should be taken before a mean because it increases insulin release

Repaglinide. It is absorbed rapidly in the GI tract. Benzoic acid derivative.

28

Sitagliptin

Dipeptide Peptidase 4 inhibitor...prevents breakdown of incretins which increase GLP1 function. May be good to use with Exanatide?