Flashcards in Endocrinology - Hypothyroidism Deck (60)
What does TBG stand for?
thyroid hormone binding globulin
What does TSH stand for?
thyroid stimulating hormone - thyrotropin
What does TRH stand for?
Thyrotropin releasing hormone
What does T4 stand for?
What does TgAA stand for?
What does T4AA stand for?
What does NTI stand for?
What does ED stand for? (in relation to the thyroid not male pee pee issues)
What does RIA stand for?
The thyroid hormone has a lot of functions. It is important to keep in mind that ___ ______ ______ escapes the adverse effects of excess or insufficiency.
No organ system
What is the major secreted thyroid hormone?
What is the major biologically active thyroid hormone?
Is T3 or T4 more potent?
What form of hormone, bound or unbound, is biologically active and able to mediate regulatory feedback?
The unbound (free) form
What are the 2 major categories of primary hypothyroidism?
Lymphocytic thyroiditis or idiopathic thyroid degeneration
What is lymphocytic thyroiditis?
Lymphocytic infiltration with progressive destruction of thyroid follicles
How can inflammation in cases of lymphocytic thyroiditis be measureD?
In the serum by measuring antibodies to thyroid components - usually thyroglobulin
True or False: You will see clinical signs well before extensive damage by lymphocytic thyroiditis occurs.
False - extensive destruction occurs before clinical signs of hypothyroidism develops
What is idiopathic thyroid degeneration?
Loss of thyroid parenchyma and then replaced by adipose and fibrous tissue
What breeds are over represented by hypothyroidism?
Doberman, golden retriever, labrador retriever, and cocker spaniel
When do clinical signs due to hypothyroidism typically develop?
in middle aged animals
What general clinical signs are associated with hypothyroidism?
Decreased metabolic rate, skin/haircoat changes (most common), neurologic, ocular, and myxedema coma
What clinical signs are associated with decreased metabolic rate?
lethargy, dullness, weight gain without polyphagia
What skin/haircoat changes are associated with hypothyroidism?
Alopecia, hyperpigmentation, and pyoderma
What neurologic clinical signs are associated with hypothyroidism?
Peripheral neuropathy, central vestibular disease, subclinical myopathy, and less commonly (seizures, laryngeal paralysis, megaesophagus, MG, and others)
What ocular clinical signs are associated with hypothyroidism?
What is a myxedema coma?
life-threatening hypothermia, bradyarrhythmias, and rapid deterioration in the mental state
What clinical pathology is associated with hypothyroidism?
Normocytic, normochromic, non-regenerative anemia (30% of dogs), hypercholesterolemia (75% of dogs), hypertriglyceridemia, and a normal UA
What thyroid screening test is used to rule out hypothyroidism?
Total thyroxine (TT4)