Flashcards in Oncology - Lymphoma/Leukemia 2 Deck (90)
Define stage I lymphoma.
Involvement of LN or organ
Define stage II lymphoma.
Involvement of 1 or more regional lymph nodes
Define stage III lymphoma.
Generalized LN involvement
Define stage IV lymphoma.
Define stage V lymphoma.
Bone marrow involvement or other organs
Define substage A.
Healthy - absence of significant clinical signs
Define substage B.
Sick - clinical signs attributable to systemic disease
True or False: Stage I-IV have a similar prognosis.
Which substage has a worse prognosis?
What are the diagnostic methods that can aid in staging?
Abdominal rads and/or ultrasound
If you are going to do the bare minimum for staging, what tests should be done?
CBC, chemistry, and UA
*A dog with lymphoma being presented with peripheral lymphadenopathy and uveitis would be classified with what stage of disease?
a. Stage 1
b. Stage 2
c. Stage 3
d. Stage 4
e. Stage 5
e. Stage 5
What are the different types of immunophenotyping that can determine the difference between B cell or T cell lymphoma?
What is the gold standard for immunophenotyping between B and T cell lymphoma?
What samples do immunohistochemistry use?
What samples do immunocytochemistry use?
What are the advantages of knowing if it is B cell or T cell lymphoma?
May change treatment options
How do you test for lymphocyte clonality?
PCR for antigen receptor rearrangement
What does a polyclonal PARR response indicate?
What does a monoclonal PARR response indicate?
What is PARR performed on?
Blood, bone marrow, lymph node aspirates, effusion, and mediastinal mass
What does PARR test for?
clonality to distinguish reactive lymphocytosis vs. lymphoma (slide says leukemia but I feel like its a typo)
What is flow cytometry performed on (in the context of lymphoma)?
Blood, bone marrow, LN, effusion, and mediastinal mass
What does flow cytometry test for?
a panel of antibodies - phenotype, subtype, MHCII, etc.
What percentage of lymphoma cases are B cell?
Does B cell or T cell lymphoma have a better prognosis?
B cell lymphoma
Where are T cell lymphomas commonly found?
Skin, mediastinum, GI, and hepatic
Does B cell or T cell lymphoma have a better response to the CHOP protocol?
*Which one of the following lymphoma diagnostics evaluates clonality of the lymphocyte population?
b. Flow cytometry