Energy Regulation and Obesity Flashcards Preview

Hugh's MD1 Abdominal > Energy Regulation and Obesity > Flashcards

Flashcards in Energy Regulation and Obesity Deck (29):
1

Which neurotransmitters suppress appetite?

MSH

CART

2

What percentage of energy expenditure is accounted for by basal metabolic rate?

65-75%

2

What is the function of leptin?

Signal to the brain how much fat one has

3

What is the postulated affect of insulin on the liver?

Increase appetite

5

How much of obesity is genetically determined?

70%

6

How does the metabolism of obese people compare to non-obese?

Same

7

Where in the brain are HPY, AGRP, MSH and CART produced?

Arcuate nucleus

7

How is leptin transported into the brain?

A receptor on the choroid plexus

8

Which category is fidgeting included in?

Activity

9

What do long chain fatty acids do to appetite?

They suppress it

9

How does glucose and nutrients suppress appetite?

They inhibit the beta-oxidation of low chain fatty acids (an appetite suppressor and beta-oxidation inactivated LCFAs)

10

How much energy is stored in 1gram of fat?

7000cal

11

Which part of the brain controls appetite?

Hypothalamus 

12

What are some causes of spontaneous weight loss?

Thyrotoxicosis

Untreated type 1 diabetes

CF

Infection

Malignancy

13

What is anorexia defined as?

Loss of 25% of original body weight

14

Which neurotransmitters stimulate appetite?

NPY

AGRP

15

What are 3 techniques of measuring total energy expenditure?

Whole room respiratory chambers

Metabolic carts

Double labelled water

15

What accounts for the increase in the prevalence of obesity?

Epigenetics

16

T/F Obese people lack leptin?

False, they are insensitive to it

17

That amount of the leptin produced is proportional to what?

The amount of fat on the body

19

What happens to fidgeting when one forced into caloric surplus?

Fidgets increases 

21

What happens when Orexin is knocked out in mice?

Narcolepsy 

22

How does eating effect the thermogenesis energy expenditure?

Increases it

23

Will all people who are forced overfed gain weight?

No, some do and some don't

24

Which cell synthesizes leptin?

Adipocytes

26

What was abnormal with db/db mice?

Leptin receptor

27

What happens when insulin is injected into the brains of mice?

They eat less

28

What was abnormal with ob/ob mice?

Lack leptin

29

T/F Obese people's leptin functions normally

False, they have a polymorphism that prevents it from functioning