Liver, pancreatic secretions and jaundice Flashcards Preview

Hugh's MD1 Abdominal > Liver, pancreatic secretions and jaundice > Flashcards

Flashcards in Liver, pancreatic secretions and jaundice Deck (53)
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1

What is the name of food when it exits the stomach?

Chyme

1

At what level must blood bilirubin by at for jaundice to occur?

35 micromolar - 3x the normal amount

2

What does colipase do?

Activates lipase 

Prevents bile acids inhibiting the lipase

2

What population gets pancreatitis the most?

Females >50

2

Why do a high proportion of babies get jaundice?

Is there is a lot of haemolysis during the switch from foetal to adult Hb and the liver it's yet developed enough to deal with the extra load. 

3

What happens when fatty acids enter to intestinal mucosa?

Reform triglycerides

4

Which pancreatic cells release bicarbonate?

Duct cells

4

What drug can be used to decrease fat absorption?

Orlistat

5

What are bile salts made from?

Cholesterol

6

What does CCK do to the gallbladder?

Stimulates contraction

6

Which pancreatic cells release enzymes?

Acinar

6

What serum markers are indicative of pancreatitis?

Lipase (most characteristic)

Amylase

6

Is Gilbert's syndrome severe? What goes wrong?

No, usually subclinical

Decreased conjugation of bilirubin

8

What are zymogens?

Inactivated precursor forms of enzymes

9

What happens to faeces after a fatty meal?

It's darker due to more bile

10

What is a hepatic cause of jaundice?

Intrahepatic obstruction - cirrhosis

11

What activates colipase?

Trypsin

12

How much bile can the liver produce per day?

Up to 1L

13

What is the function of the taurine and glycine groups on bile salts?

Increase solubility

14

What is cyst a general term for?

A Bladder-like structure

15

What structure does bile acids form in digested lipids?

Micelles

15

What happens in Dubin-Johnson syndrome? Is it severe?

Impaired secretion of conjugated bilirubin

Mild symptoms

16

What does secretin enhance the secretion of?

Bicarbonate in the acinar cells of pancreas

17

What happens when you have a deficiency in glucose-6-phosphate dehydrogenase?

You can't produce as much glutathione (glutathione protects against ROSs) > More ROS > RBCs damaged

18

What percentage of bilirubin comes from the breakdown of old RBCs?

80%

19

What endocrine hormones do islets of Langerhan make?

Insulin

Glucagon

20

How does increasing the fat cotent of faeces affect its appearance?

Paler, whiter

Greasy

Foul smelling

22

What is enterohepatic circulation?

Where bile salts are absorbed in the terminal ileum for recycling

23

What happens when you go on chloroquine when you have a deficiency in G6PD?

ROS from chloroquine aren't removed by glutathione > membrane destruction and globin precipitation > haemolytic jaundice, Heinz bodies

25

What type of agents are bile salts?

Detergents