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Medical Immunology Bios 443/843 > Exam # 1 > Flashcards

Flashcards in Exam # 1 Deck (23):
1

Which TLRs recognize pathogenic nucleic acids?

TLRs 3,7,9

2

Which molecule is important for tight neutrophil adhesion?

LFA-1

3

The Fab fragment of the antibody molecule

binds antigen

4

What is the best definition of an endogenous Pyrogen?

Cytokines made by the host that increase body temperature

5

Mannose Binding Lectin, an example of secreted PRR, helps in facilitating pathogen uptake by a processes known as...

Opsonization

6

Most Toll like receptors signal through an adaptor protein called MyD88. However, _____ is a MyD88 independent signaling receptor.

TLR3

7

Junctional Diversity during gene rearrangement results from the addition of _____

P and N nucleotides

8

Which of the following corresponds to the antigen binding site of immunoglobulins?

VH; VL

9

The Signaling pathways triggered by toll like receptors typically result in activation of the following pairs of which transcription factors?

NFkB and AP-1

10

The 110 AAs that make up the Fab fragment of the H and L chains consist of ______ and ______ regions

framework ad hypervariable

11

B Cells are said to be anergic if they have seen/ undergone:

Moderate levels of soluble antigen followed by migration to the periphery

12

The Process by which a pathogen stimulates only those lymphocytes with receptors specific for that pathogen is called

Clonal selection

13

Early, innate events during viral infection of host cells involves induction of the cytokine ______ that activates _______ to kill virally infected cells

IFN-a/B, NK cells

14

Which Cytokine is important for B cell development?

IL-7

15

What would be the phenotype of a mouse (or a person) that lacks tdt?

Less diversity in the lymphocyte repertoire

16

Name the three categories of PRRs and cite an example of each

1) Endocytic : Macrophage Mannose Receptor; 2) Signaling: TLRs; 3) Secreted: Mannose Binding Lectin

17

A disease known as X- linked Agammaglobulinemia is characterized by a lack of antibodies, but normal numbers of CD4 and CD8 T cells. a. what is the defect in these patients (In which gene does the defect reside?)

Defect in BTK gene; located in long arm of chromosome xq22

18

A disease known as X- linked Agammaglobulinemia is characterized by a lack of antibodies, but normal numbers of CD4 and CD8 T cells. b. What is the developmental consequence of this defect? In other words, at which stage in lymphocyte development will this defect manifest?

Post pre B cell receptor; BTK lies downstream of the Pre-B cell receptor and causes signals to be transduced that allow the B-Cell to survive. XLA lacks or has a mutation in BTK that does not allow this to occur.

19

XLA phenotype

No tonsils; mutation in BTK; absence of B cells, normal T cell levels

20

Omenn Syndrome phenotype

red rash, mutation in Rag1/2; absence of B cells, low levels of T cells.

21

What binding receptor is on a rolling leukocyte? What is its ligand?

LFA-1; ICAM-1

22

What is CXCL8's role in leukocyte rolling?

CXCL8 is a chemokine that binds to leukocyte and causes LFA-1 to go from low affinity to high affinity binding.

23

What is the first checkpoint in B cell development?

The large pre B cell; tests for the presence of a heavy rearranged chain

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