Jeopardy 11/24/15 Flashcards Preview

Medical Immunology Bios 443/843 > Jeopardy 11/24/15 > Flashcards

Flashcards in Jeopardy 11/24/15 Deck (27):
1

This CD4 T cell subset is important in maintaining tolerance in the periphery

What are Tregs?

2

This dendritic cell expresses high levels of TLR7, TLR9 and secretes Type I interferons

Plasmacytoid DCs; Combat Viral infections

3

T Cell production of this cytokine promotes IgG3 class switching:

IFNg

4

What immunoglobulin class does IL-4 promote?

IgE

5

All memory T cells express high levels of this marker

CD44

6

What is the surface marker allows entry into the lymph node?

CD62L

7

What is the chemokine receptor that allows naive T cells to migrate to the lymph node?

CCR7

8

Which kinase phosphorylates ITAMS to begin the TCR signaling cascade?

What is LCK? ITAMS are the cytoplasmic tail of CD3, CD3 interacts with the TCR.

9

DCs express this marker for migration from the tissues to the draining LN

CCR7

10

The expression of this chemokine receptor promotes B and T cell migration to the follicle

CXCR5; present on T follicular helper cells (subset)

11

B Cells require this type of CD4 T cell for effective memory responses

T follicular helper cells; if you knock these out, then memory B cell development is impaired.

12

This molecule on activated T cells binds B7-1:B7-2 and signals cells to limit proliferation

CTLA-4

13

This term refers to the ability of B cells to produce IgG, IgA or IgE after receiving T cell help

What is Class Switching

14

This transcription factor "fixes" differentiation to the Th17 subset

What is ROR-gamma T

15

What does Stat 3 do?

signal tranducers downstream from cytokine receptors. (IL-6 for Stat 3)

16

This cytokine is produced after TCR signaling and CD28 ligation

What is IL-2? induces proliferation

17

Tissue resident memory cells express this cell surface marker_______ while central memory cells express____________

for central memory cells: CCR7/CD62L/ CD44hi; Tissue resident memory cells CD103

18

The idea that activated T cells demonstrate asymmetric proliferation in which one daughter cell becomes an effector and the other daughter cell becomes the memory cell is known as:

The bifurcative differentiation model

19

Linear differentiation model

Assumes that memory cells are derived from effector cells.

20

B7-1:B7-2 on the DC binds to this molecule on naive T cells

CD28

21

Conventional, activated DC in the draining lymphn node participate in a non conventional mode of Ag presentation to activate naive CD8 T cells

What is cross presentation?

22

This T helper subset secretes IFNg in response to viral infections

Th1

23

Tissue resident DC express low levels of these markers compared to activated in the draining lymph node

MHCII/B71/2/IL-12/IL-2/IL-6/CCR7 for migration

24

This cell surface marker (cytokine receptor) marks memory CD8 cells that participate in the recall response

IL-7R

25

What two cytokines are important for maintaining CD8 Memory cells?

IL-7/IL-15

26

Cells found in the sinus of the LN, good at phagocytosing large particulates

Macrophages

27

Which cell is the best at receptor mediated endocytosis

B cell

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