Jitt # 5 Case # 8 MHC Class II Deficiency Flashcards Preview

Medical Immunology Bios 443/843 > Jitt # 5 Case # 8 MHC Class II Deficiency > Flashcards

Flashcards in Jitt # 5 Case # 8 MHC Class II Deficiency Deck (8):
1

MHC II presents antigens to which type of T-Cell

CD4+

2

What type of peptides do MHC II molecules express? Meaning, what type of pathogens are involved in MHC II expression?

Extracellular pathogens or proteins, or pathogens that persist intracellularly inside vesicles

3

What type of cells are MHC II molecules expressed on?

APCs; DC, macrophages, B lymphocytes, activated T-cells, activated epithelial cells, activated thymus * activated by interferon gama

4

What type of cytokine upregulates the expression of MHC II molecules?

Interferon gamma

5

What are the three classes of MHC II molecules?

DP, DQ, DR

6

CD20

B Cells

7

MHC II Deficiency

Low Ig levels; deficiency of CD4+ Cells Lack HLA-DR; autosomal recessive trait;

8

What is a possible treatment for MHC II deficiency?

Bone marrow transplant, but the results are often unsatisfactory.

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