Jitt # 15 Multiple Sclerosis Flashcards Preview

Medical Immunology Bios 443/843 > Jitt # 15 Multiple Sclerosis > Flashcards

Flashcards in Jitt # 15 Multiple Sclerosis Deck (7):
1

What antigens in the myelin can cause MS?

myelin based protein (MBP); proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein (MOG).

2

Which HLA subclass is MS associated with?

HLA-DR2

3

What are symptoms associated with MS?

Urinary incontinence, blindness, ataxia, muscle weakness, paralysis of the limbs. sclerotic plaques in brain;

4

Which CD4+ subset is involved with MS?

Th1; MHC II; Th17 also plays a role

5

a4B1 integrin

receptor for VCAM on the surface of a t cell; capable of binding to VCAM and entering the brain.

6

Pathophysiology of MS

1) CNS antigens escape the brain, present to lymphoid organs 2) Th1 cells generated 3) travel and enter the brain by a1B4 - VCAM interactions 4) microglial cells (APCs in the CNS) present antigen to the T cells causing inflammation (IFNg release) . 5) Increases vascular permeability causing the leak of more macrophages and Th1 cells in the brain, which produce more inflammatory cytokines.

7

Microglial cells

Macrophage like cells that are resident to the CNS.

Decks in Medical Immunology Bios 443/843 Class (56):