Objectives and Vocabulary for Week Eight Flashcards Preview

Medical Immunology Bios 443/843 > Objectives and Vocabulary for Week Eight > Flashcards

Flashcards in Objectives and Vocabulary for Week Eight Deck (14):
1

Nu/Nu mice

Nude Mice; lack a thymus; show deficiency in T Cell Development

2

SCID

Severe Combined Immuno-deficiency; caused by mutation in Rag1/2 genes; causes issues in recombination of receptors; notable loss of lymphocytes

3

Notch-1

Transcription Factor that is responsible for commitment to T cell lineage

4

X-Linked SCID

Mutation in gamma chain, causes inability of IL-7, IL-2, and IL-15 to be recognized by their receptors. Causes block in T cell and NK cell development, but normal B cell development.

5

Notch-1

Along with Gata-3 are the transcription factors important for HSC commitment to the T Cell lineage

6

Double Positive Cells

Cells are CD8+/CD4+; TCR a rearrangement, expression of TCRab heterodimer occur in DP stage.

7

When does the rearrangement of the alpha chain occur? What causes its induction?

rearrangement of the alpha chain occurs in the late Pre-T cell stage, due to 2nd wave of Rag1/2 expression.

8

Double Negative Cells

Most immature; no TCR, CD3, z chain, CD4 or CD8; considered to be a pro-T Cell stage.

9

Single Positive Cells

CD4+ or CD8+; undergo negative selection; arise post positive selection

10

CD44

Involved in leukocyte adhesion to endothelial cells and extracellular matrix

11

CD25

(IL-2Ra) Enables activated T cells to respond to growth promoting cytokine IL-2

12

CD40L

Post antigen recognition, 24-48 hours, T Cells up regulate CD40L , enables activated T cells to mediate their key effector functions, which are to help macrophages and B cells.

13

Pre-TCR

Rearranged TCR B chain, Pre-Ta, CD3, z proteins; only if B chain is rearranged correctly, gives survival signals.

14

Pre-Ta

invariant chain similar to light chain in B cell development. Important in the function of the Pre-TCR and proliferation of the Thymocyte.

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