Flashcards in Jitt # 5 Case # 12 MHC Class I Deficiency Deck (15):
What class of MHC is located on all cells, except for RBCs?
Class I MHC; CD8+
What kind of infections do MHC Class I/CD8+ fight against?
What response do CD8+ cells have against MHC I cells expressing viral PAMPS?
1) Release Perforin (pore forming protein) 2) cytotoxic granzymes 3) TNF alpha 4) lymphotoxin
What are the three types of Class I MHC in humans?
HLA-A, HLA-B, HLA-C
What enzyme complex degrades viral DNA?
What proteins transport viral peptides from the cytosol into the ER?
TAP1 & TAP2; Both are located on the ER membrane
Where are TAP 1 & TAP2 genes encoded?
In the region containing Class II genes
Tapasin; facilitates the interaction of MHC I molecules with TAP1/2, and its antigenic peptides
Dialation of the bronchi from repeated infection
Non sense mutation
mutation that causes the translation of a mRNA segment prematurely
MHC Class I Deficiency
Caused by a missense mutation in the gene that encoded TAP2; reduction in CD8+ T cells is caused by a reduction in the amount of MHC I expression. No MHC, No maturation.