Jitt # 5 Case # 12 MHC Class I Deficiency Flashcards Preview

Medical Immunology Bios 443/843 > Jitt # 5 Case # 12 MHC Class I Deficiency > Flashcards

Flashcards in Jitt # 5 Case # 12 MHC Class I Deficiency Deck (15):
1

What class of MHC is located on all cells, except for RBCs?

Class I MHC; CD8+

2

What kind of infections do MHC Class I/CD8+ fight against?

Viral infections

3

What response do CD8+ cells have against MHC I cells expressing viral PAMPS?

1) Release Perforin (pore forming protein) 2) cytotoxic granzymes 3) TNF alpha 4) lymphotoxin

4

What are the three types of Class I MHC in humans?

HLA-A, HLA-B, HLA-C

5

What enzyme complex degrades viral DNA?

Proteasomes

6

What proteins transport viral peptides from the cytosol into the ER?

TAP1 & TAP2; Both are located on the ER membrane

7

Where are TAP 1 & TAP2 genes encoded?

In the region containing Class II genes

8

TAPBP

Tapasin; facilitates the interaction of MHC I molecules with TAP1/2, and its antigenic peptides

9

Bronchiectasis

Dialation of the bronchi from repeated infection

10

CD19

B-Cells

11

CD16

NK cells

12

CD3

T Cells

13

Non sense mutation

mutation that causes the translation of a mRNA segment prematurely

14

MHC Class I Deficiency

Caused by a missense mutation in the gene that encoded TAP2; reduction in CD8+ T cells is caused by a reduction in the amount of MHC I expression. No MHC, No maturation.

15

CD14

Macrophages

Decks in Medical Immunology Bios 443/843 Class (56):