Jitt # 5 Case # 12 MHC Class I Deficiency Flashcards Preview

Medical Immunology Bios 443/843 > Jitt # 5 Case # 12 MHC Class I Deficiency > Flashcards

Flashcards in Jitt # 5 Case # 12 MHC Class I Deficiency Deck (15)
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1
Q

What class of MHC is located on all cells, except for RBCs?

A

Class I MHC; CD8+

2
Q

What kind of infections do MHC Class I/CD8+ fight against?

A

Viral infections

3
Q

What response do CD8+ cells have against MHC I cells expressing viral PAMPS?

A

1) Release Perforin (pore forming protein) 2) cytotoxic granzymes 3) TNF alpha 4) lymphotoxin

4
Q

What are the three types of Class I MHC in humans?

A

HLA-A, HLA-B, HLA-C

5
Q

What enzyme complex degrades viral DNA?

A

Proteasomes

6
Q

What proteins transport viral peptides from the cytosol into the ER?

A

TAP1 & TAP2; Both are located on the ER membrane

7
Q

Where are TAP 1 & TAP2 genes encoded?

A

In the region containing Class II genes

8
Q

TAPBP

A

Tapasin; facilitates the interaction of MHC I molecules with TAP1/2, and its antigenic peptides

9
Q

Bronchiectasis

A

Dialation of the bronchi from repeated infection

10
Q

CD19

A

B-Cells

11
Q

CD16

A

NK cells

12
Q

CD3

A

T Cells

13
Q

Non sense mutation

A

mutation that causes the translation of a mRNA segment prematurely

14
Q

MHC Class I Deficiency

A

Caused by a missense mutation in the gene that encoded TAP2; reduction in CD8+ T cells is caused by a reduction in the amount of MHC I expression. No MHC, No maturation.

15
Q

CD14

A

Macrophages

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