Guest Lecture: Autoimmunity Flashcards Preview

Medical Immunology Bios 443/843 > Guest Lecture: Autoimmunity > Flashcards

Flashcards in Guest Lecture: Autoimmunity Deck (18):
1

Paraoxysmal Cold Hemoglobinuria

PCH; Rare disease where exposure to cold causes a patient's RBS to lyse; Donath and Landsteiner performed plasma experiment to show that it has an autoimmune etiology

2

What are the components of PCH?

1) Target Cells 2) Thermolabile substance (present in normal and disease serum; complement) 3) Thermostabile substance (present only in disease; bound to RBCs; autoantibodies)

3

Major T cell mediated diseases

Type I diabetes; MS; IBD; Psoriasis

4

Major B cell/ Antibody mediated disease

Rheumatoid Arthritis (also T cell mediated); Systemic Lups Erythematosus; Myasthenia Gravis; Grave's Disease

5

What are the five factors in autoimmunity?

1. Genetics 2. Environment 3. Failure of tolerance 4. Aberrant cellular responses 5. Target cells/Tissues

6

What is the predictive gene behind many autoimmune diseases?

MHC II; for many autoimmune diseases, there are susceptible and protective MHCII alleles

7

What are the Treg associated mutations and their diseases?

AIRE - APECED; FoxP3 - IPEX

8

What cytokine increase is associated with Lupus?

Type I interferons

9

Inflammation's effects on APCS

1) Increased maturity 2) increase in inflammatory mediators 3) increase costimulatory proteins

10

Inflammation's effects on B cells

1) Mature to plasma cells 2) increases inflammatory mediators 3) increased reception to T cell stimulation

11

Inflammation's effects on T cells

1) increases proliferation 2) biases to Th1 and Th17 3. Can increase or reduce apoptosis 4) Refractory to regulation.

12

What tissue is targeted in MS

Myelin on neurons

13

What tissue is targeted in IBD

intestine

14

What tissue is targeted in retinitis?

the retina

15

What tissue is targeted in SLE

DNA, nuclear antibodies

16

What tissue is targeted in RA

synovium, antibodies (Rheumatoid factor)

17

What tissue is targeted in Myasthenia gravis

acetylcholine receptors on muscles.

18

Treatments for autoimmune disorders

Removal of triggers, gene therapy, bone marrow transplants, change microenvironment, depress immune cells, boost regulation, antigen specific therapy

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