Jitt # 7 APECED Flashcards Preview

Medical Immunology Bios 443/843 > Jitt # 7 APECED > Flashcards

Flashcards in Jitt # 7 APECED Deck (9):
1

APECED

Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (Also known as APSI); human autosomal recessive disease; Mutation in AIRE (which is not encoded by MHC genes);

2

What cell types play the most important role in negative selection?

Bone-Marrow derived DCs and Macrophages; Thymic medullary epithelial cells also play a role.

3

Symptoms of APECED

Decreased growth; inadequate growth hormone; high levels of TSH; antibodies against endocrine glands, liver, and skin; increased susceptibility to infection with candida albicans; abnormalities in skin, teeth and fingernails;

4

Which cytokines do patients with APECED have antibodies against?

IL-17A, IL-17E, and IL-22. These are important cytokines in controlling fungal infections.

5

Negative selection

Single Positive thymocytes who bind to antigens in the thymic medulla with high avidity undergo apoptosis.

6

Central Tolerance

Induced when developing
lymphocytes encounter self antigens in the
primary or generative lymphoid organs (thymus
and bone marrow)

7

Peripheral Tolerance

Induced when mature lymphocytes encounter self antigens in peripheral tissues.

8

What is the fate of thymocytes that bind with intermediate affinity?

They become Treg. Regulatory T Cells.

9

Generation of Treg

Occurs in the thymus; Thymocytes bind with intermediate affinity; Transcription factor FoxP3 upregulated; Treg moves to the periphery and inhibits self reactive T cells.

Decks in Medical Immunology Bios 443/843 Class (56):