Exam 2, Anticoagulant drug CIS, martin Flashcards Preview

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Flashcards in Exam 2, Anticoagulant drug CIS, martin Deck (21):
1

What is PT

prothrombin time for extrinsic pathway

2

What is INR for warfarin therapy

2-3

3

what is aPTT

activated thromboplastin time

4

Are DVTs red clots or white clots

red

5

What tests shoul dbe performed before DVT Tx

Hct, PT, aPTT, platelet count and stool sample for occult blood

6

why do you use heparin to help with a DVT

because thrombolytic could lead to serious bleeding

7

With a DVT, how would you administer heparin

loading dose to get levels up fast then constant rate

8

with active pulm embolism what therapy is immediately started

heparin therapy for 5 days
warfarin inditiated day 1 and continued 3-6 months

9

What does INR stand for

international normalization ratio

10

With patient in A fib what threapy should you initiate? and for how long until cardioversion procedure

anticoagluant because risk of embolism from A fib is very high
low intesnsity warfarin theraphy to an INR 2-3
3 weeks prior to cardioversion

11

What is the antiplatelet agent of choice in patients with vascular disease of any origin

aspirin

12

what drug acts by being an agonist for peroxisome proliferator-activated receptor alpha

fibrate

13

what genetic changes incholesterol pathway are expected with statin therapy

increased expression LDL R because overall decrease of cholesterol intracellularly

14

how do statins work on VLDL

decrease expression

15

after taking a stain for one week paitent complains of leg and arm pain, what could acount for this

increased creatine kinase

16

what cholesterol absorption inhibitor can be prescribe with atovastatin to further decrease LDL levels

ezetimibe

17

fibrates are most effective for elevation in what: TG or LDL?

TG elevation

18

what is most common side effect of niacin

skin rash

19

how do you prevent niacin skin rash side effect

prophylactic ibuprofen

20

how do you calculate percentage decrease of LDL levels

(original minus current) / original

21

what is a precaution of bile acid sequesterants when patient is on other medication

have to separate administeration time of 4 hours because bile acid one can sequester the other drug