Exam 2 antihyperlipidemics- Kinder Flashcards Preview

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Flashcards in Exam 2 antihyperlipidemics- Kinder Deck (73)
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1

What are statins

HMG-CoA reductase inhibitors

2

what are the fibrate drugs

fenofibrate
gemfibrozil

3

what are the bile acid sequesterants

cholestyramine
colesevelam
colestipol

4

what are the cholesterol absorption inhibitors

ezetimibe

5

vytorin is a comination of what drugs

simvastatin and ezetimibe

6

what are the new Tx out for homozygous familial hypercholesterolemia

lomitapide
mipomersen

7

what are the major components of chylomicrons

dietary TGs and cholesterol

8

where are chylomicrons synthesized

intestine

9

what is the mechanism of catabolism of chylomicrons

TG hydrolysis by LPL and remant uptake by liver

10

What is LDL make up of

cholesteryl esters

11

what is HDL made up of

phospholipids, cholesteryl esters

12

what lipoproteins are made in the liver

VLDL and HDL

13

which lipoprotein has the most protein

HDL

14

which lipoprotein has the most lipid

chylomicrons

15

how do plaques form, general path sequence

LDL retention in subendothelial space leading to oxidation that increases plasminogen inhibitor and inhibits NO
massive accumulation of cholesterol with increased inflammatory response

16

What are the targe LDL choesterol levels and what is considered very high

want 190 very high

17

what is the target for total cholesterol and what is considered high

want 240 high

18

what are the normal ranges of HDL

60 is high

19

What is the LDL goal for CHD or CHD risk eqivalent?
at what LDL level do you intiate drug therapy

goal LDL 130

20

what is the LDL goal for patients with 0-1 risk factors? when do you start Tx

goal 190

21

What are the risk equivalents for CHD

symtomatic carotid artery disease
peripheral arterial disease
AAA
diabetes

22

what are the risk factors for hyperlipidemia

age
family Hx of premature CHD
cigarette smoking
HTN
low HDL

23

what are non drug Tx options for HLD

lifestyle changes, diet, exercise, smokin cessation

24

what are the drug Tx options for HLD

MHG-CoA Reductase Inhibitors (statins)
Niacin, Vit B3
Fibric Acid dervatives (fibrates)
bile acid sequestrants (resins)
cholesterol absorption inhibitors

25

non drug Tx for HLD should not be used alone in what scenarios

severe hypercholestermia
known CHD
CHD risk equivalents
PVD

26

what are the dietary recs for HLD

total fat 20-25% calories
saturated fat <200 mg
carbs 50-60% total calories
dietary fiber 20-30 g

27

What parts of diet increase TGs?

alcohol, total fat, excess caloric intae

28

what parts of diet increase LDL

cholesterol, saturated and trans fats

29

What is HMG-CoA reductase

the rate limiting enzyme in cholesterol synthesis

30

which statins have longer half lives

atorvastatin and rosuvastatin