Exam 3, adrenergic drugs DSA Flashcards Preview

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Flashcards in Exam 3, adrenergic drugs DSA Deck (47):
1

What are the alpha adrenergic agonists

epi and norepi

2

what are the beta adrenergic agonists

isoproterenol
dobutamine (b1)
epi and norepi

3

what R dose dopamine work on

D1, B1 , a1

4

what R does fenoldopam work on

D1

5

what type of drugs are clonidine and methyldopa

alpha 2 agonists

6

what are the alpha selective antagonists

prazosin (a1)
phentolamine (a1 a2)

7

what are the nonselective beta antagonists

propranolol, nadolol, timolol, pindolol, carteolol
sotalol esmolol

8

what are the cardioselective beta blockers

atenolol, acebutolol
metoprolol

9

what are the 3rd generation beta blockers

labetolol, carvedilol, betaxolol, carteolol

10

how do norepi, epi and isoproterenol affect pulse rate

nor epi drops it
epi and isoproterenol increase it

11

how do norepi, epi and isoproteronl affect peripheral R

norepi increases alot
epi decreases slightly
isoproterenol decreases alot

12

what are the net results of norepi, epi and isoproterenol on BP

increased in norepi
same in epi
same, maybe slight dec in isoproterenol

13

epi primarly effects ehart how

working through B1 R to increase inotropy (force) and increase chronotropy (HR)

14

explain vascular effects of epi

work on alpha 1 to vasoconstrict
have higher affinity for beta 2 which causes decrease in diastolic BP

15

how does epi affect renin

increased via beta1

16

when do we use epi therpeutically for heart

restore cardiac rhythm in those in cardiac arrest
after 1-2 CPR cycles and defibrillation
also to Tx bradycardia with serious signs and symptoms

17

describe effects of norepi on heart

direct chronotropic effect that stimulates vagal reglex to slow the heart and SV is increased

18

How do we use norepi thepetuically for heart

used as a vasoconstrictor to raise or to support BP under certain intesnsive care conditions
not in shock

19

What is primary action of dopamine

vasodilate renal and mesenteric vascular beds

20

what is mechanism of dopamine

increase [ ] of cAMP
vasodilation

21

how is dopamine used to treat heart

can help with shock and CHF by excreting more Na
can cause an increase in CO

22

what if you gave a little too much dopamine to someone with cardiogenic shock

can actually cause general vasoconstriction and lead to more problems in shock

23

what is fenoldopam used for to Tx

severe HTN

24

When is dobutamine used in heart problems

short term tx cardiac decompensation like after surgery or in patients with CHF or AMI

25

how does dobutamine work on CO and SV and HR

increase CO SV
no change in HR

26

when is isoproterenol used

emergencies to stimulate HR in patients with bradycardia or heart block
usually just befor epacemaker placement

27

which beta blockers also block alpha R

labetolol and carvedilol

28

which betablocker has agonist activity at Beta 2

carteolol

29

which bet blockers activate NO production

nebivolol, carteolol

30

which beta blockers block Ca entry

carvedilol and betaxolol

31

beta 1 selective antagonists are preferredin what patients

bronchospasm, diabetes, peripheral vascular disease, Raynauds

32

which betablockers antagonize alpha 1 and stimulate beta 2

the third generation ones

33

how do beta blockers affect heart

decrease work, reduce myocardial O2 consumption
increase O2 demand by increased EDpressure

34

do beta blockers decrease mortatlity of HF

yes

35

how do beta blockers chnag eHR

brady

36

why can immediate withdrawl of beta blockers cause sudden death

from upregulation of R

37

What are beta blokcesr used to Tx

HTN, angina, acute coronary syndromes, CHF
also for supraentricular and ventricular arrhythmias

38

what are the effects of use of beta blockers in patients with HF from L ventricular systolic dysfunction

improve function, life quality and prolong life

39

how do you administer beta blockers for first time

low dose and slowly increase

40

are beta blockers useful in ealry AMI

shown to dec mortality by 25%

41

what is used to tx hypertrophic obstructive cardiomyopathy

propanolol

42

why are beta blockers useful in acute dissectin aortic aneurysm

reduction force contraction

43

what is most appropriate drug for hyperthyroidism that is causing CV signs

beta blocker

44

What is metoprolol used to Tx

essential HTN, agina pectoris, tachycardia, HF, vasovagal syncope and as secondary prevention after MI, adjunct in hyperthyroidism and for migrain prophylaxis

45

What is atenolol used to Tx

HTN, coronary heart disease, arrhythmias, agina, reduce risk heart complications after MI
Graves

46

what is commonly used to Tx supraventricular tachcardias

esmolol
because rapid onset

47

what are the affects of carvedilol in patients with mild to severe CHF

improves ventricular function and reduces mortality and morbidity