Exam 2, Blood vessels part 2, gomez Flashcards Preview

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Flashcards in Exam 2, Blood vessels part 2, gomez Deck (33):
1

What is giant cell arteritis associated with

>50 and with polymyalgia rheumatica

2

what is the most common vasculitis of elderly in US

giant cell arteritis

3

what can giant cell arteritis cause clinically

diplopia and permanent blindness
may cause giant cell aortitis and thoracic aortic aneurysm
can involve coronary aa
2/3 have anti-endothelial or anti-smooth muscle Ab

4

What is Takayasu arteritis

granulomatous inflammation of aorta and major branches
usually females

5

what are signs of takayasu arteritis

marked weakeneing os pulses and reduced BP in upper extremities
retinal hemorrhages and blindess
sometimes pulmonary and renal HTN

6

describe findings in polyarteritis nodosa

young adults
renal arterial involvemnt causes deaths, no glomerulonephritis
30% have hep B surface Ag/Ab complexes

7

what are symptoms of polyarteritis nodosa

malaise, fever, weight loss, HTN, abdominal pain, melena, muscular aches/pains, ulcers, infarcts, peripheral neuritis (mostly motor)

8

What is Tx for polyarteritis nodosa

steroids and cyclophosphamide

9

what type of necrosis occurs with polyarteritis nodosa

fibrinoid

10

what is the cause of kawasaki disease

anti-endothelial cell and smooth muscle autoAb

11

what is the main cause of acquired pediatric heart disease in North Aerica and Japan

kawasaki disease

12

what are signs and symptoms of kawasaki disease

fever, conjunctival and oral erythema (strawberry tongue!)
erosion edema of hands and feet
erythema palms and soles
desquamative skin rash and enlarged cervical lymph nodes

13

what syndrome is kawasaki disease assoc with

mucocutaneous lymph node syndrome

14

What ANCA is assoc with microscopuc polyangiitis

p ANCa MPO

15

what are signs and symptoms of microscopic polyangiitis

palpable purpura
necrotizing glomerulonephritis
pulmonary capillaritis
hemoptysis, arthralgia, abdominal pain or bleeding, hematuria, proteinuria, hemorrhage and muscle pain or weakness

16

what is the eosinophil rich small vessel vasculitis

churg strauss syndrome

17

what is churg strauss syndrome associated with

allergic rhinitis, bronchial asthma, lung infiltrates and blood eosinophilia

18

what ANA is churg strauss syndrome assoc with

pANCA and MPO

19

what are signs and symptoms of small vessel vasulitis

palpable purpura
coronary arteritis and eosinophilic myocarditis

20

what is behcet disease

neutrophilic vasculitis of small to medium aa

21

what is the triple sy,ptom complex of behcets

recurrent oral apthous ulcers, genital ulcers and uveitis

22

what gene is behcet associated with

HLA B51

23

what is a pathergy test and which vasulitis is it associated with

a minor trauma like sterile pinprick causes huge exagerated reaction
behcet

24

What is the triaf in wegener granulomatosis

acute necrotizing granulomas of upper and lower respiratory tract
necrotizing or granulomatous vasculitis affecting small to medium vessels in lungs mainly
renal disease (usually crescenteic GN with hemturia and sometimes proteinuria

25

what ANCA is associated with wegener

PR3 ANCA c ANCA

26

what type of necrosis do lungs undergo in wegeners

caseous

27

clinical presentation of wegeners

M>F ~ 40 yrs
persistnet pneumonitis, b/l nodular and cavity infiltrates
chronic sinusitis
mucosal ulcerations in nasopharynx
renal disease
skin rashes
muscle pains
articular involvemnet
fever

28

what is Tx for wegeners

immunosuprresion (steroids, chemo and anti-TNF)

29

what is thromboangiitis obliterans

segemental thrombosing acute anc chronic inflammation of medium sized and smallarteries
extends to veins and nerves

30

what are signs of thromboangiitis obliterans (buerger disease)

beings before age 35
chronic ulcerations of toes, feet or fingers and gangrene
exercise induced instep claudication
severe pain

31

What is thromboangiitis obliterans associated with

heavy cigarrete smoking

32

what other disorders can have vasculitis

rheumatoid arthritis, SLE, malignancy, mixed cryoglobulinemia and Henoch-Schonlein purpura

33

how do you trate lupus vasulitis vs antiphospholipid Ab syndrome

aggressive anti inflammartory Tx vs aggressive anticoagluant therapy