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Flashcards in FA Basic Bacteriology Deck (28):
1

what do you call the group of bugs that use an O2-dependent system to generate ATP.

Obligate aerobes

2

What are the four obligate aerobes?
Hint: Nagging Pests Must Breathe

Nocardia
Pseudomonas aeruginosa
Mycobacterium tuberculosis,
Bacillus

3

What is an aerobe that is seen in burn wounds, complications of diabetes, nosocomial pneumonia, and pneumonias in CF patients?

Pseudomonas aeruginosa

4

What things might reactivate TB?

Immune compromise or TNF-alpha inhibitor use

5

Reactivation fo M tuberculosis has a predilection for WHAT?

the apices of the lung, which have the highest PO2.

6

What are the three obligate anaerobes?
Hint: anaerobes Can't Breathe Air

Clostridium,
Bacteroides,
Actinomyces

7

Name two things that obligate anaerobes may lack that makes them susceptible to oxidative damage.

Catalase and/or Superoxide dismutase.

8

Name three characteristics of obligate anaerobes

1. foul smelling (short chain fatty acids)
2. difficult to culture
3. produce gas in tissue (CO2, H2)

9

Why are obligate anaerobes foul smelling?

Short-chain fatty acids

10

Why type of gases do obligate anaerobes produce in culture?

CO2 and H2

11

Anaerobes are normal where and pathogenic where?

Normal in GI tract, pathologic everywhere else.

12

Why are aminoglycosides ineffective against anaerobes?

these antibiotics require O2 to enter into bacterial cell.

13

What type of antibiotic is not effective against anaerobes because it requires O2 to get into the bacterial cell?

Aminoglycosides

14

Name three bugs against which aminoglycosides are ineffective

Clostridium
Bacteroides
Actinomyces.

15

What are the two obligate intracellular bugs?

Rickettsia, Chlamydia (can't make own ATP)
Stay inside (cells) when it's Really Cold.

16

What are the facultative intracellular bugs?
Some Nasty Bugs May Live FacultiveLY

Salmonella,
Neisseria,
Brucella,
Mycobacterium,
Listeria,
Francisella,
Legionella,
Yersinia Pestis

17

What bugs have a positive quelling reaction?

Encapsulated bacteria

18

What is a positive quelling reaction.

capsule swells when specific anticapsular antisera are added.

19

What are the seven encapsulated bacteria.
SHiNE SKiS

1. Strep pneumo
2. H flu type B
3. Neisseria meningitidis
4. E coli
5. Salmonella
6. Klebsiella
7. Group B strep

20

How are encapsulated bacteria cleared from the body?

Opsonized and then cleared by spleen.

21

Why are asplenics at increased risk for serious infections from encapsulated organisms?

Decreased opsonizing ability

22

What vaccines should you give your asplenic patients?

S pneumo, H flu, N meningitis

23

The capsules of encapsulated bacteria serve as what?

an antiphagocytic virulence factor.

24

Capsule + what serve as an antigen in vaccines?

Protein conjugate

25

What are the catalase positive organisms?
PLACESS for your cat

Pseudomonas
Listeria
Aspergillus
Candida
E coli
Staph aureus
Serratia

26

Catalase degrades H2O2 before it can be converted to microbicidal products by what enzyme?

Myeloperoxidase

27

People with what disease have increased susceptibility to catalase positive organisms?

Chronic granulomatous disease (NADPH oxidase deficiency)

28

Why do people with CGD have increased susceptibility to catalase positive organism infection?

Because the bacteria degrade the limited H2O2.