Flashcards in FA Basic Bacteriology Deck (28):
what do you call the group of bugs that use an O2-dependent system to generate ATP.
What are the four obligate aerobes?
Hint: Nagging Pests Must Breathe
What is an aerobe that is seen in burn wounds, complications of diabetes, nosocomial pneumonia, and pneumonias in CF patients?
What things might reactivate TB?
Immune compromise or TNF-alpha inhibitor use
Reactivation fo M tuberculosis has a predilection for WHAT?
the apices of the lung, which have the highest PO2.
What are the three obligate anaerobes?
Hint: anaerobes Can't Breathe Air
Name two things that obligate anaerobes may lack that makes them susceptible to oxidative damage.
Catalase and/or Superoxide dismutase.
Name three characteristics of obligate anaerobes
1. foul smelling (short chain fatty acids)
2. difficult to culture
3. produce gas in tissue (CO2, H2)
Why are obligate anaerobes foul smelling?
Short-chain fatty acids
Why type of gases do obligate anaerobes produce in culture?
CO2 and H2
Anaerobes are normal where and pathogenic where?
Normal in GI tract, pathologic everywhere else.
Why are aminoglycosides ineffective against anaerobes?
these antibiotics require O2 to enter into bacterial cell.
What type of antibiotic is not effective against anaerobes because it requires O2 to get into the bacterial cell?
Name three bugs against which aminoglycosides are ineffective
What are the two obligate intracellular bugs?
Rickettsia, Chlamydia (can't make own ATP)
Stay inside (cells) when it's Really Cold.
What are the facultative intracellular bugs?
Some Nasty Bugs May Live FacultiveLY
What bugs have a positive quelling reaction?
What is a positive quelling reaction.
capsule swells when specific anticapsular antisera are added.
What are the seven encapsulated bacteria.
1. Strep pneumo
2. H flu type B
3. Neisseria meningitidis
4. E coli
7. Group B strep
How are encapsulated bacteria cleared from the body?
Opsonized and then cleared by spleen.
Why are asplenics at increased risk for serious infections from encapsulated organisms?
Decreased opsonizing ability
What vaccines should you give your asplenic patients?
S pneumo, H flu, N meningitis
The capsules of encapsulated bacteria serve as what?
an antiphagocytic virulence factor.
Capsule + what serve as an antigen in vaccines?
What are the catalase positive organisms?
PLACESS for your cat
Catalase degrades H2O2 before it can be converted to microbicidal products by what enzyme?
People with what disease have increased susceptibility to catalase positive organisms?
Chronic granulomatous disease (NADPH oxidase deficiency)