FA Endotoxins & Bacterial Growth Flashcards

1
Q

A lipopolysaccharide found in outer membranes of gram-negative bacteria

A

Endotoxin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the most important endotoxin of which to be aware?

A

Lipid A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

FA says ENDOTOXIN should make you think:

A
Edema
Nitric oxide
DIC/Death
Outer membrane
TNF-alpha
O-antigen
eXtremely heat stable
IL-1
Neutrophil chemotaxis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

endotoxin (esp lipid A) has three primary (first) effects:

A
  1. Activates macrophages
  2. Activates complement
  3. Activates tissue factor
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Endotoxin –> activates macrophages –> (three effects)

A

IL-1, TNF-alpha, NO

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

IL-1 –>

A

Fever

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

TNF-alpha –>

A

Fever and hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

NO –>

A

Hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Endotoxin –> complement activation –> 2 things

A

c3a & c5a

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

C3a –>

A

hypotension + edema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

C5a –>

A

neutrophil chemotaxis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

endotoxin –> tissue factor activation –>

A

coagulation cascade –> DIC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what do you call the period of bacterial growth in which there is metabolic activity without division

A

lag phase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what do you call the period of rapid cell division on the bacterial growth curve

A

exponential/log phase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

At what phase of bacterial growth do penicillins and cephalosporins act?

A

exponential/log phase (peptidoglycan is being made)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What do you call the period of bacterial growth in which nutrient depletion slows growth

A

stationary phase

17
Q

What do you call the phase of bacterial growth where there is prolonged nutrient depletion and buildup of waste production?

A

death phase

18
Q

at what phase in bacterial growth do some bacteria make spores?

A

stationary phase

19
Q

what are the four phases of bacterial growth:

A
  1. lag phase
  2. exponential growth phase
  3. stationary phase
  4. death phase