FA Gram Neg Rods II Flashcards Preview

Micro > FA Gram Neg Rods II > Flashcards

Flashcards in FA Gram Neg Rods II Deck (36):
1

What are the three most important E coli virulence factors

fimbriae
K capsule
LPS endotoxin

2

E coli fimbriae -->

cystitis & pyelonephritis

3

E coli K capsule -->

pneumonia, neonatal meningitis

4

E coli LPS endotoxin -->

septic shock

5

Invasive; dysentery;
microbe invades intestinal mucosa and causes necrosis and inflammation; clinical manifestations similar to Shigella

EIEC

6

Traveler's diarrhea (watery); produces heat-labile and heat stable enterotoxins; no inflammation or invasion

ETEC

7

Diarrhea in kids (Pediatric); no toxin produced; adheres to apical surface, flattens villi, prevents absorption

EPEC

8

What is the presentation of EHEC?

Dysentery (bloody diarrhea)

9

what is the most common serotype of EHEC?

O157:H7

10

what is the toxin produced by EHEC?

Shiga like toxin

11

how could you distinguish EHEC from other e coli?

does not ferment sorbitol

12

what does SLT of EHEC cause?

Hemolytic uremic syndrome

13

what is the triad of hemolytic uremic syndrome

Anemia + thrombocytopenia + acute renal failure

14

How does SLT cause schistocytes and decreased renal blood flow?

Microthrombi form on endothelium damaged by toxin --> mechanical hemolysis (schistocytes) + dec RBF

15

how does SLT cause thrombocytopenia?

microthrombi consume platelets

16

An intestinal flora that causes lobs pneumonia in alcoholics and diabetics when aspirated

Klebsiella

17

What are the four As associated with Klebsiella?

Aspiration pneumonia
Abscess in lungs and liver
Alcoholics
diAbetics

18

Why does Klebsiella cause very mucoid colonies?

Polysaccharide capsule

19

Red currant jelly sputum

Klebsiella

20

Nosocomial UTI

Klebsiella

21

Causes typhoid fever. Found only in humans.

Salmonella typhi

22

4 symptoms of typhoid fever

1. ROSE SPOTS on abdomen
2. fever
3. headache
4. diarrhea

23

Where can S typhi hang out and cause a carrier state?

gallbladder

24

unlike other salmonella, s typhi is found only in

humans

25

Does salmonella have flagella?

yes

26

does shigella have flagella?

no

27

How does salmonella spread throughout the body?

hematogenous spread

28

how does shigella spread throughout the body?

cell to cell transmission; no hematogenous spread

29

salmonella reservoir

many animal reservoirs

30

shigella reservoir

humans and primates

31

antibiotic effect on fecal excretion of salmonella

may prolong

32

antibiotic effect on fecal excretion of shigella

shortens

33

Salmonella invades intestinal mucosa and causes

a monocytic response

34

Shigella invades intestinal mucosa and causes

PMN infiltration

35

Does salmonella ferment lactose?

No

36

Does shigella ferment lactose?

No