Flashcards in FA Gram Neg Rods II Deck (36):
What are the three most important E coli virulence factors
E coli fimbriae -->
cystitis & pyelonephritis
E coli K capsule -->
pneumonia, neonatal meningitis
E coli LPS endotoxin -->
microbe invades intestinal mucosa and causes necrosis and inflammation; clinical manifestations similar to Shigella
Traveler's diarrhea (watery); produces heat-labile and heat stable enterotoxins; no inflammation or invasion
Diarrhea in kids (Pediatric); no toxin produced; adheres to apical surface, flattens villi, prevents absorption
What is the presentation of EHEC?
Dysentery (bloody diarrhea)
what is the most common serotype of EHEC?
what is the toxin produced by EHEC?
Shiga like toxin
how could you distinguish EHEC from other e coli?
does not ferment sorbitol
what does SLT of EHEC cause?
Hemolytic uremic syndrome
what is the triad of hemolytic uremic syndrome
Anemia + thrombocytopenia + acute renal failure
How does SLT cause schistocytes and decreased renal blood flow?
Microthrombi form on endothelium damaged by toxin --> mechanical hemolysis (schistocytes) + dec RBF
how does SLT cause thrombocytopenia?
microthrombi consume platelets
An intestinal flora that causes lobs pneumonia in alcoholics and diabetics when aspirated
What are the four As associated with Klebsiella?
Abscess in lungs and liver
Why does Klebsiella cause very mucoid colonies?
Red currant jelly sputum
Causes typhoid fever. Found only in humans.
4 symptoms of typhoid fever
1. ROSE SPOTS on abdomen
Where can S typhi hang out and cause a carrier state?
unlike other salmonella, s typhi is found only in
Does salmonella have flagella?
does shigella have flagella?
How does salmonella spread throughout the body?
how does shigella spread throughout the body?
cell to cell transmission; no hematogenous spread
many animal reservoirs
humans and primates
antibiotic effect on fecal excretion of salmonella
antibiotic effect on fecal excretion of shigella
Salmonella invades intestinal mucosa and causes
a monocytic response
Shigella invades intestinal mucosa and causes
Does salmonella ferment lactose?