FA Gram Neg Rods II

Question 1

What are the three most important E coli virulence factors

Answer 1

fimbriae
K capsule
LPS endotoxin

Question 2

E coli fimbriae –>

Answer 2

cystitis & pyelonephritis

Question 3

E coli K capsule –>

Answer 3

pneumonia, neonatal meningitis

Question 4

E coli LPS endotoxin –>

Answer 4

septic shock

Question 5

Invasive; dysentery;

microbe invades intestinal mucosa and causes necrosis and inflammation; clinical manifestations similar to Shigella

Answer 5

EIEC

Question 6

Traveler’s diarrhea (watery); produces heat-labile and heat stable enterotoxins; no inflammation or invasion

Answer 6

ETEC

Question 7

Diarrhea in kids (Pediatric); no toxin produced; adheres to apical surface, flattens villi, prevents absorption

Answer 7

EPEC

Question 8

What is the presentation of EHEC?

Answer 8

Dysentery (bloody diarrhea)

Question 9

what is the most common serotype of EHEC?

Answer 9

O157:H7

Question 10

what is the toxin produced by EHEC?

Answer 10

Shiga like toxin

Question 11

how could you distinguish EHEC from other e coli?

Answer 11

does not ferment sorbitol

Question 12

what does SLT of EHEC cause?

Answer 12

Hemolytic uremic syndrome

Question 13

what is the triad of hemolytic uremic syndrome

Answer 13

Anemia + thrombocytopenia + acute renal failure

Question 14

How does SLT cause schistocytes and decreased renal blood flow?

Answer 14

Microthrombi form on endothelium damaged by toxin –> mechanical hemolysis (schistocytes) + dec RBF

Question 15

how does SLT cause thrombocytopenia?

Answer 15

microthrombi consume platelets

Question 16

An intestinal flora that causes lobs pneumonia in alcoholics and diabetics when aspirated

Answer 16

Klebsiella

Question 17

What are the four As associated with Klebsiella?

Answer 17

Aspiration pneumonia
Abscess in lungs and liver
Alcoholics
diAbetics

Question 18

Why does Klebsiella cause very mucoid colonies?

Answer 18

Polysaccharide capsule

Question 19

Red currant jelly sputum

Answer 19

Klebsiella

Question 20

Nosocomial UTI

Answer 20

Klebsiella

Question 21

Causes typhoid fever. Found only in humans.

Answer 21

Salmonella typhi

Question 22

4 symptoms of typhoid fever

Answer 22

1. ROSE SPOTS on abdomen
2. fever
3. headache
4. diarrhea

Question 23

Where can S typhi hang out and cause a carrier state?

Answer 23

gallbladder

Question 24

unlike other salmonella, s typhi is found only in

Answer 24

humans

Question 25

Does salmonella have flagella?

Answer 25

yes

Question 26

does shigella have flagella?

Answer 26

no

Question 27

How does salmonella spread throughout the body?

Answer 27

hematogenous spread

Question 28

how does shigella spread throughout the body?

Answer 28

cell to cell transmission; no hematogenous spread

Question 29

salmonella reservoir

Answer 29

many animal reservoirs

Question 30

shigella reservoir

Answer 30

humans and primates

Question 31

antibiotic effect on fecal excretion of salmonella

Answer 31

may prolong

Question 32

antibiotic effect on fecal excretion of shigella

Answer 32

shortens

Question 33

Salmonella invades intestinal mucosa and causes

Answer 33

a monocytic response

Question 34

Shigella invades intestinal mucosa and causes

Answer 34

PMN infiltration

Question 35

Does salmonella ferment lactose?

Answer 35

No

Question 36

Does shigella ferment lactose?

Answer 36

No