Flashcards in FINAL - TS Deck (109):
What antiviral is used for pain?
Amantadine (m2 ion channel inhibitor)
What antifungal is used for respiratory infections?
Which 2 antifungals do not act on membrane or cell wall?
Griseofulvine (mitotic spindles)
Pyramidine analog (DNA synthesis)
What are the SE of polyene mycotics (amphotericin B)?
renal, endothelial irritant, hypokalemia
What anti-fungal inhibits squalene epoxidase?
What antiprotozoal has CV effects in horses and guinea fowl?
What anti-protozoal binds disulphide bridges?
What is the MOA of organophosphates?
irreversible inhibition of AChE
What is the MOA of carbamates?
reversibile inhibition of AChE
What receptors do pyrethrins and pyrethroids act on?
sodium channels, GABA, nicotinic
What are the SE of pyrethrins and pyrethroids?
nerve and muscular disorders, dont use in cats
How is resistance acquired against pyrethroids?
decrease in sensitivity of target site
What receptors do macrocyclic lactones act on? (according to werner)
Glutamate, GABA, glycine
What is the MOA of fipronil?
GABA and glutamate
What ectoparasiticide inhibits chitin synthesis?
What is the MOA of amitraz? (formamidine)
inhibits MAO (also alpha 2 receptors?)
Which diuretic has the least amount of bone loss?
What are the extra-renal effects of thiazide diuretics?
What drug blocks AT1 receptor and is used for chronic renal failure?
What drugs can be used for the prostate?
basic and lipophilic drugs, erythromycins
What drugs are used for incontinence on the bladder?
What drugs are used for incontinence on the sphincter?
What drugs cause dilation of the pupil?
What drugs cause constriction of pupil?
What antifungal does not penetrate cornea?
polyene antibiotics (amphotericin B)
What drugs are combined with plasma serum to put on eye?
EDTA or acetylcysteine
What drugs act on trabecular ouflow?
What drugs act on uveoscleral outlfow?
What drugs act on aqueous humor inflow?
beta 2 blockers
alpha 2 agonists
What antimycotic is used for aspergillosis?
What is the effect of bromhexine and dembrexin?
increase mucous gland evacuation
What 4 drug groups modify airway resistance?
anticholinergics, beta 2 agonists, sympathetic amines, phosphodiesterase inhibitors
What alkylating chemotherapy drug has low BM toxicity?
What is the MOA of alkylating drugs?
carbonium ion --> dna synthesis
What is the MOA of plant derivative chemo drugs?
What are the SE of prostaglandin alpha 2 analogs?
colic, increased muscle tone, GI signs, retained placenta
What sulfonamide is for opthalmic use?
What are the SE of sulfonamides?
KCS, hepatic necrosis, thyroid
How are sulfonamides metabolized?
What are the extended spectrum/anti-pseudomonal beta lactams?
ticarcillin, carbenicillin, piperacillin, mezlocillin, azlocillin
What cephalosporin is distributed to CSF fluid?
What beta lactam has low immunogenic profile?
aztreonam (a monobactam)
What antibiotic drug group has neuromuscular blockade for SE?
What is the drug of choice for equine ehrlichia?
How are chloramphenicols metabolized?
What is the drug of choice for campylobacter jejuni?
What antibiotic group inhibits translocation at the 50s subunit?
What is the drug of choice for mycoplasma?
What antibiotic causes overgrowth in hind gut fermenters and is fatal?
What antibiotic group accumulates in macrophages?
What are the SE of fluoroquinolones?
arthropathy, ocular, inhibits GABA
What antibiotic group results in histamine release?
What antibiotic group inhibits energy metabolism by blocking oxidative decarboxylation of coA?
What drugs can methenamine not be used with?
What antibiotic drug group is good for giardia and anaerobic bacteria?
What is the centrally acting emetic for dogs? cats?
dogs - apomorphine
cats - xylazine
What drug antagonizes apomorphine emesis?
What drug blocks substance P emesis?
What is the contraindication of maripotant citrate?
puppies less than 11 weeks, BM
What is the most potent H2 receptor antagonist of antisecretory drugs?
What antisecretory drug can be used in patients with acute hepatic problems?
What is the broadest prokinetic agent?
What are the opiods that decrease motility?
morphine, fentanyl, meperidine, diphenoxylate, difenoxin, loperamide, paragoric
What is used for sand colic?
What is lactulose used for?
What contracts gall bladder by increasing SO4?
What is the MOA of digitalis?
What inotropic drug increases binding of muscle to calcium?
pimobendan (also a vasodilator)
What are the characteristics of pimobendan?
antiarrythmic, inotropic, vasodilator, no effect on oxygen consumption
What vasodilator has minimal reflex tachycardia?
What drugs are contraindicated with ace inhibitors?
What do class IA antiarrythmics do?
shorten phase 0
also prolong AP
What is the most broad spectrum anti-arrythmic drug?
What 2 classes prolong AP?
class 1 and 3
What class can not be used with beta blockers?
class 4 (calcium antagonists)
What kind of drug is dilitiazem?
What antiarrythmic should not be given to halogenetade anesthetics?
What antiarrythmic drugs are used for high levels of catecholamines?
beta blockers (propranolol and metoprolol)
What is dopamine used for in the cardiovascular system?
oliguric renal failure
What is netobimin a prodrug of?
What is the MOA of benzimidazoles?
irreversible binding to microtubulin
What antinematodal drug is a immune stimulant?
What is anoplocephela perfoliata treated with?
What treats pinworms in horses?
pyrantel pamoate salt
What treats whipworms such as trichuris sp?
dichlorvos - pellets!
What is the MOA of macrocyclic lactones?
glutamate gated chloride channels - paralysis
What drug is used for screwworms?
What is the contraindication of piperazine?
intestinal impaction of dead worms
What is the MOA of piperazine?
GABA agonist - paralysis
What drug for rumen flukes?
What is the MOA of praziquantel?
calcium ion flux - vacuoles
What does rafoxanide treat?
immature flukes and adult flukes
What antitrematodal is injectable?
What drug is effective against haemonchus contortus?
What antitrematodals are extensively PP bound?
rafoxanide and closantel
What is the MOA of diamphenethide?
amine metabolite 100% against immature flukes
What is the MOA of hydralazine and minoxidil?
opening of K+ channels in artery muscle
What vessels does nitroglycerin relax?
mostly large veins
What is the MOA of Isoxsuprine?
beta 2 agonist - dilates skeletal muscle BV
What drug is used for canine pulmonary hypertension and what is MOA?
sildenafil,, phosphodiesterase V inhibitor, inhibit cGMP degredation, relax pulmonary BV
What is the MOA of enalapril?
inhibit peptidyl dipeptidase to convert angiotension, also inhibit bradykinin degredation
What is the MOA of isoproterenol?
beta 1 and 2 agonist, emergency heart block
What is the alpha glusidase inhibitor?
What is the gila monster drug?
What insulin has no peak?
What is the MOA of azoles?
What is the MOA of piperonyl butoxide?
inhibits MFO of insect
What is the MOA of thiazide diuretics?
inhibit Na/Cl symport