Flashcards in Repro Drugs Deck (30):
What neurotransmitters regulate GnRH neuronal firing?
What stimulates GnRH release?
What reduces GnRH release?
Opioids (inhibit NE release) & GABA
When does dopamine have an inhibitory effect?
What increases GnRH pulse frequency?
Estrogen POSITIVE feedback
Which hormone slows down GnRH pulse frequency?
Progesterone NEGATIVE feedback --> decr. LH
GnRH receptors are coupled to _____ receptors.
List 6 steps in GnRH receptor signaling
1. Activation of phospholipase C
2. Generation of IP3 & DAG
3. Mobilization of intracellular Ca
4. Activation of PKC
5. PKC activates MAP kinase
6. LH & FSH synthesis & release
What leads to GnRH/gonadotropin receptor down regulation?
Gonadorelin is a synthetic ______ analogue.
Indication for intermittent dosing of Gonadorelin.
Indications for continuous dosing of Gonadorelin. (TQ)
Chemical castration or limit estrus
List the 4 gonadotropins.
% homology between LH & hCG. (TQ)
Which subunit confers specificity (TQ)?
FSH & LH are ____ coupled receptors linked to ______ ________.
adenylate cyclase --> increase cAMP
What is the gonadotrophic activity of eCG?
sufficient LH activity to induce ovulation & luteinization
S.E. of oxytocin use in animals
Forceful contractions of all smooth mm. --> can induce colic, etc.
PGF2-alpha acts on _______ receptors linked to ______.
IP3 & Ca activation of protein kinase C.
4 S.E.s of prostaglandin analogs.
1. incr smooth mm. tone --> diarrhea, abdominal pain, bronchoCONSTRICTION, incr. BP
2. Small animals- vomiting
3. Retained placenta after abortion
4. Abortion-if handled by pregnant women
What is the specific use of PGF2-alpha in mares?
TX mating induced persistent endometritis
MOA of progesterone analogs.
incr. suppression of LH & FSH
(acts on progesterone receptors in hypothalamus & pituitary gland)
All anabolic adrenal steroids are derived from _______.
In high doses, what other drugs can be used to mimic the effects of anabolic steroids?
Beta 2 agonists
Clinical effects of anabolic steroids.
Increases: myelopoiesis, production of EPO, strength & vitality, appetite, protein production
Steroid receptors are _____.
Alkylated anabolic steriod with strong anabolic and weak androgenic effects.
Non-alkyalating anabolic steriod
4 S.E.s of Stanazolol & Nandrolone
Stanazolol - wt gain due to Na & H2O rentention