Repro Drugs Flashcards Preview

Pharmacology > Repro Drugs > Flashcards

Flashcards in Repro Drugs Deck (30):
1

What neurotransmitters regulate GnRH neuronal firing?

GABA
NE
Dopamine
Opioids/endorphins

2

What stimulates GnRH release?

NE

3

What reduces GnRH release?

Opioids (inhibit NE release) & GABA

4

When does dopamine have an inhibitory effect?

Non-breeding season

5

What increases GnRH pulse frequency?

Estrogen POSITIVE feedback

6

Which hormone slows down GnRH pulse frequency?

Progesterone NEGATIVE feedback --> decr. LH

7

GnRH receptors are coupled to _____ receptors.

Gq

8

List 6 steps in GnRH receptor signaling

1. Activation of phospholipase C
2. Generation of IP3 & DAG
3. Mobilization of intracellular Ca
4. Activation of PKC
5. PKC activates MAP kinase
6. LH & FSH synthesis & release

9

What leads to GnRH/gonadotropin receptor down regulation?

continuous stimulation

10

Gonadorelin is a synthetic ______ analogue.

GnRH

11

Indication for intermittent dosing of Gonadorelin.

Infertility therapy

12

Indications for continuous dosing of Gonadorelin. (TQ)

Chemical castration or limit estrus

13

List the 4 gonadotropins.

LH
FSH
hCG
eCG

14

% homology between LH & hCG. (TQ)

82%

15

Which subunit confers specificity (TQ)?

beta

16

FSH & LH are ____ coupled receptors linked to ______ ________.

G-protein
adenylate cyclase --> increase cAMP

17

What is the gonadotrophic activity of eCG?

1ry- FSH-like
sufficient LH activity to induce ovulation & luteinization

18

S.E. of oxytocin use in animals

Forceful contractions of all smooth mm. --> can induce colic, etc.

19

PGF2-alpha acts on _______ receptors linked to ______.

Gq
IP3 & Ca activation of protein kinase C.

20

4 S.E.s of prostaglandin analogs.

1. incr smooth mm. tone --> diarrhea, abdominal pain, bronchoCONSTRICTION, incr. BP
2. Small animals- vomiting
3. Retained placenta after abortion
4. Abortion-if handled by pregnant women

21

What is the specific use of PGF2-alpha in mares?

TX mating induced persistent endometritis

22

MOA of progesterone analogs.

incr. suppression of LH & FSH

(acts on progesterone receptors in hypothalamus & pituitary gland)

23

All anabolic adrenal steroids are derived from _______.

Cholesterol

24

In high doses, what other drugs can be used to mimic the effects of anabolic steroids?

Beta 2 agonists

25

Clinical effects of anabolic steroids.

Increases: myelopoiesis, production of EPO, strength & vitality, appetite, protein production

26

Steroid receptors are _____.

Ligand-activated

27

Alkylated anabolic steriod with strong anabolic and weak androgenic effects.

Stanazolol

28

Non-alkyalating anabolic steriod

Nandrolone

29

4 S.E.s of Stanazolol & Nandrolone

Stanazolol - wt gain due to Na & H2O rentention
Hepatotoxic
Carcinogenicity
Teratogenicity

30

Why would you use synthetic compounds over natural hormones?

If the natural hormone has a short 1/2 life