Respiratory Drugs Flashcards Preview

Pharmacology > Respiratory Drugs > Flashcards

Flashcards in Respiratory Drugs Deck (31):
1

What 2 drugs can be used more effectively to TX Aspergillosis locally in dogs? (TQ)

Enilconazole
Clotrimazole

2

What are the 3 systemic imidazoles?

Ketoconazole
Fluconazole
Voriconazole

3

What is the major S.E. of imidazoles?

Inhibits CYP450

4

Which drugs can be used to locally TX Guttural Pouch Mycosis in equines?

Thiobendazole
Nystatin
Enilconazole

5

Anti-tussives should only be used when?

Only w/ severe NON-PRODUCTIVE cough

6

What are the opioids used as anti-tussives?

Codeine
Hydrocodone
Butorphanol
Dextromethorphan

7

Which opioids have limited S.E.?

Codeine
Hydrocodone

8

Anti-tussive w/ low potency & weak CNS suppression. Used in horses & cattle (TQ)

Dextromethorphan

9

Which drug has beneficial effects in horses (BAL procedure)?

Butorphanol

10

How does Acetylcystiene modify airway mucus?

Breaks up by disrupting disulphydryl bonds

11

A _____ of respiratory lumen will lead to an increase of resistance. (TQ)

Decrease
(diameter/2 = resistance*16)

12

What 3 classes of drugs can you use to modify airway resistance? (TQ)

ACH M3 ANTagonists
Beta 2 agonists
PDE-inhibitors

13

What 4 drugs can be used to stimulate respiration?

Crotethemaide
Lobeline
Doxapram
Etamiphylline

14

What 3 drugs can be used to suppress the cough reflex?

Codeine phosphate
Hydrocodone
Dihydrocodone

15

What 4 drugs can be used to modify airway mucus consistency?

N-acetylcystein
Bromhexine
Ambroxol
Dembrexine

16

What 2 drugs are stimulating expectorants?

Guajacol
Guaifenisine

17

What 3 drugs are reflex expectorants?

Ammonium carbonate
Ammonium chloride
Potassium iodide

18

What is a non-specific anticholingeric drug used to modify airway resistance?

Atropine
(ER only)

19

What anticholingeric can be used to evaluate responsiveness in COPD?

Butylscopolamine

20

Which 3 anticholingeric drugs can you administer per inhalation? (stays local & don't need [high])

Ipratropium bromide
Oxitropium bromide
Tiotropium bromide

21

What are the 3 effects of beta 2 agonists binding to the G-protein coupled receptor? (know)

1. activates adenylate cyclase
2. incr. cAMP production
3. activates of PKA
4. bronchoDILATION

22

What are the 3 Beta-2 agonists used to modify airway resistance? (know)

Clenbuterol
Salbutamol
Albuterol

23

Which alpha1- adrenergic decongestant causes reflex vasoDILATION?

Phenylephrine

24

What are the phosphodiesterase inhibitors used to modify airway resistance?

Xanthine
Methylxanthine
Theophylline (most used clinically)

25

MOA of Theophylline.

Believed to inhibit PDE--> incr. cAMP--> incr. mucociliary clearance

26

Never give NSAIDs under what conditions?

Acute severe bronchoconstriction --> DEATH
Asthma (aspirin induced asthma)

27

What are the 2 mast cell stabilizers? (TQ)

Sodium cromoglicate
Nedocromil sodium

28

What are the 4 ways glucocorticoids help reduce inflammation & inhibit mediator release?

stabilize membranes
reduce mucosal edema
suppress immune rxns
sensitize smooth mm. to Beta adrenergic drugs

29

Don't combine expectorants w/ what?

Alpha adrenergics (decrease secretions)

30

What are the 3 classes of drugs commonly used as bronchoDILATORS? (TQ)

Xanthine derivatives
Anticholinergics
Beta agonists

31

4 steps to bronchoCONSTRICTION via Ach M3 Activation. (TQ)

1. PIP2 ---> IP3 & DAG by PhosphoLIPASE C
2. DAG= activates phosphoKINASE C
3. IP3= Ca release & Calmodulin complexes
4. smooth mm. contraction