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Flashcards in FN: IBD: Pathology and Presentation Deck (21):
1

UC
Prevalence
Age
Sex
Aetiology

1. 100-200/100,000
30w
F>M
Concordance = 10%
Smoking protective
TH2-mediated

2

Crohns
Prevalence
Age
Sex
Aetiology

50-100/100,000
Smoking increases risk
Th1/Th7 mediated

3

UC macroscopic
Location
Ditribution
Strictures?

1. Rectum + colon ± backwash ileitis
2. Distribution contigupus
3. Strictures No

4

Crohns Macroscopic
Location
Dstribtuion
Strictures?

1. Mouth to anus esp. terminal ileum
2. skip lesions
3. TEs

5

UC microscopic
1. inflammation
2. Ulceration
3. fibrosis
4. Granulomas
5. Pseudopolyps
6. fistulae

1. Mucosal
2. shallow, broad
3. None
4. None
5. Marked
6. No

6

Crohns
1. inflammation
2. Ulceration
3. fibrosis
4. Granulomas
5. Pseudopolyps
6. fistulae

1. Transmura
2. Deep thin, serpiginous --> cobblestone mucosa
3. Marked
4. Present
5. Minimal
6.

7

Uc symptoms

Systemic: fever, malaise, anorexia, wt. loss in active disease
Abdominal:
1. diarrhoea
2. blood ± mucus PR
3. Abdominal discomfort
4. Tenesmus, faecal urgency

8

Crohns symptoms

systemic: fever, malaised, anorexia, wt. loss in active disease
abdominal:
1. diarrhoea (not usually bloody)
2. Abdominal pain
3. Wt. loss

9

UC signs abdominal

fever
Tender, distended abdomen

10

Crohns signs abdomen

Apthous ulcers, glossitis
2. abdominal tenderness
3. RIF mass
4. Perianal abscessess, fistulae, tages
5. Anal/rectal strictures

11

UC and crohns extra-abdominal skin

Skin:
1. clubbing
2. erythema nodosum
3. pyoderma gang (esp. Uc)

12

UC and crohns extra-abdominal eyes

1. iritis
2. Conjunctivitis
3. Episcleritis
4. Scleritis

13

UC and crohns extra-abdominal joints

Arthritis (non-deforming, asymmetrical)
sacroilitis
Ank spond

14

UC and crohns extra-abdominal HPB

PSC + cholangiocarcinoma (esp. UC)
Gallstones
Fatty liver

15

UC and crohns extra-abdominal other

Amyloidosis
Oxalate renal stones (esp. Crohns)

16

Complications UC

1. Toxic megacolon (risk of perf)
2. bleeding
3. Malignancy - CRC in 15 w/ pancolitis for 20 yrs
Cholangiocarcinoma
Strictures - obstruction
Venous thrombosis

17

Complications Crohns

Fistulae
Stricture
Abscesses
Malabsorption

18

Fistulae

Entero=enteric/colonic --> diaarhoea
Enerterovesical --> freqeuncy, UT
Enterovaginal
Perianal - pepperpot anus

19

Stricture lead to

Obstruction

20

Abcessess

Abdomina
anorectal

21

Malabsorption

Fat - steatorrhoea, gallstones
B12 - megaloblastic anaemia
3. Vit D --> osteomalacia
Protein - oedema
toxic megacolon and Ca

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