FN: Non-hodgkins Lymphoma Flashcards Preview

Final Notes > FN: Non-hodgkins Lymphoma > Flashcards

Flashcards in FN: Non-hodgkins Lymphoma Deck (15):
1

Features

Lymphadenopathy: 75% @ presentation
Extranodal
B symptoms

2

Lymphadenopathy

Painless
Symmetric
Multiple sites
Spreads discontinously

3

Extranodal

Skin: esp T cell Lymphomas
CNS
Oropharynx and GIT
Splenomegaly

4

B symptoms

Fever
Night sweats
Wt. loss (>10% over 6mo)

5

Blood shows

Pancytopenia
Hyperviscosity
RBC, U+E, LFT, LDH (raised worse prognosis)

6

Bloods films show

Normal or circulating lymphoma cells ± pancytopenias

7

Classification

LN and biopsy

8

Staging

CT/MRI chest, abdomen, pelvis - stage with Ann Arbor system

9

Classification

B cell (high or low grade) or T cell

10

B cell low grade

Usually indolent but often incurable
1. Follicular
2. Small cell lymphocytic (=CLL_
3. Marginal zone (inc. MALTomas)
4. Lymphoplamsacytoid (e.g. Waldenstroms)

11

High grade types

Aggresive but may be curable
Diffuse large B cell (commonest NHL)
Burkitts

12

T cell types

1. Adult T cell Lymphoma: Caribs and Japs = HTLV-1
2. Enteropathy-assoc. T cell Lymphoma: chronic coeliac
Cutaneous T cell Lymphoma e.g. sezary syn
Anaplasticarge cell

13

Management

Diagnosis and management in an MDT

14

High grade management

R-CHOP regimen
BMT for relapse
30% 5 yrs

15

Low grade (e.g. follicular) Rx

When clinically indicated (e.g. chloambucil)
50% 5 yrs

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